The serine-glycine-one-carbon (SGOC) metabolic pathway is critical for DNA methylation,
histone methylation, and redox homeostasis, in addition to protein, lipid, and nucleotide …

One-carbon metabolism is a central metabolic pathway critical for the biosynthesis of several
amino acids, methyl group donors, and nucleotides. The pathway mostly relies on the …

Many bacterial species are represented by a pan-genome, whose genetic repertoire far
outstrips that of any single bacterial genome. Here we investigate how a bacterial pan …

Fluorouracil (5-FU) is a key component of chemotherapy for colorectal cancer (CRC). 5-FU
efficacy is established by intracellular levels of folate cofactors and DNA damage repair …

Simple Summary The stress-responsive transcription factor NRF2 (nuclear factor-erythroid 2
p45-related factor 2) directs cellular metabolic processes that can have diverse effects in the …

Colorectal cancer (CRC) is the third most common cancer in men and the second most
common cancer in women worldwide. CRC is the second leading cause of cancer-related …

Mutations in the KEAP1–NRF2 (Kelch-like ECH-associated protein 1–nuclear factor-
erythroid 2 p45-related factor 2) pathway occur in up to a third of non–small cell lung cancer …

Metabolic reprogramming is a key hallmark of cancer and shifts cellular metabolism to meet
the demands of biomass production necessary for abnormal cell reproduction. One-carbon …

Circular RNAs (circRNAs) are a new series of noncoding RNAs (ncRNAs) that have been
reported to be expressed in eukaryotic cells and have a variety of biological functions in the …

Serine has been recently identified as an essential metabolite for oncogenesis, progression,
and adaptive immunity. Influenced by many physiologic or tumor environmental factors, the …