[HTML][HTML] Tumor hypoxia and radiotherapy: a major driver of resistance even for novel radiotherapy modalities

C Beckers, M Pruschy, I Vetrugno - Seminars in Cancer Biology, 2024 - Elsevier
Hypoxia in solid tumors is an important predictor of poor clinical outcome to radiotherapy.
Both physicochemical and biological processes contribute to a reduced sensitivity of hypoxic …

Resistance to immune checkpoint inhibitors in non-small cell lung cancer: biomarkers and therapeutic strategies

RJ Walsh, RA Soo - Therapeutic advances in medical …, 2020 - journals.sagepub.com
The treatment landscape for patients with advanced non-small cell lung cancer has evolved
greatly with the advent of immune checkpoint inhibitors. However, many patients do not …

Clinical practice guidelines on image-guided thermal ablation of primary and metastatic lung tumors (2022 edition)

X Ye, W Fan, Z Wang, J Wang, H Wang… - Journal of Cancer …, 2022 - journals.lww.com
The main contents of the Clinical Practice Guidelines on Image-Guided Thermal Ablation
(IGTA) of Primary and Metastatic Lung Tumors (2022 Edition) include the following …

Oligoprogressive non-small-cell lung cancer under treatment with PD-(L) 1 inhibitors

S Rheinheimer, CP Heussel, P Mayer, L Gaissmaier… - Cancers, 2020 - mdpi.com
Oligoprogression (OPD) of non-small-cell lung cancer (NSCLC) occurs in approximately half
of patients under targeted compounds (TKI) and facilitates use of regional therapies that can …

Expert consensus workshop report: Guidelines for thermal ablation of primary and metastatic lung tumors (2018 edition)

X Ye, W Fan, H Wang, J Wang, Z Wang… - Journal of Cancer …, 2018 - journals.lww.com
Although surgical resection with curative intent is the main therapy for both primary and
metastatic lung tumors, about 80% of lung cancers cannot be removed by surgery. Because …

Metastasis-directed therapy prolongs efficacy of systemic therapy and improves clinical outcomes in oligoprogressive castration-resistant prostate cancer

MP Deek, K Taparra, R Phillips, PI Velho… - European urology …, 2021 - Elsevier
Background Available therapies for castrate-resistant prostate cancer (CRPC) confer
minimal survival advantage; thus, there is interest in metastasis-directed therapy (MDT) for …

Progression patterns, treatment, and prognosis beyond resistance of responders to immunotherapy in advanced non-small cell lung cancer

Y Xu, H Li, Y Fan - Frontiers in Oncology, 2021 - frontiersin.org
Introduction Immune checkpoint inhibitors (ICIs) have changed the management of non-
small cell lung cancer (NSCLC). However, resistance is inevitable. The disease progression …

Stereotactic body radiotherapy (SBRT) for adrenal metastases of oligometastatic or oligoprogressive tumor patients

L König, MF Häfner, S Katayama, SA Koerber… - Radiation …, 2020 - Springer
Introduction Local ablative treatment strategies are frequently offered to patients diagnosed
with oligometastatic disease. Stereotactic body radiotherapy (SBRT), as ablative treatment …

The role of surgery in lung cancer treatment: present indications and future perspectives—state of the art

F Montagne, F Guisier, N Venissac, JM Baste - Cancers, 2021 - mdpi.com
Simple Summary Lung cancer evolutions, innovative systemic treatments, minimally
invasive thoracic surgery approaches and perioperative medical care have changed the role …

Current management of oligometastatic lung cancer and future perspectives: results of thermal ablation as a local ablative therapy

M Ghosn, SB Solomon - Cancers, 2021 - mdpi.com
Simple Summary Up to 56% of lung cancer patients present with metastatic disease at initial
diagnosis. Whereas these patients were historically deemed incurable, recent evidence …