The mitophagy pathway and its implications in human diseases

S Wang, H Long, L Hou, B Feng, Z Ma, Y Wu… - Signal transduction and …, 2023 - nature.com
Mitochondria are dynamic organelles with multiple functions. They participate in necrotic cell
death and programmed apoptotic, and are crucial for cell metabolism and survival …

[HTML][HTML] Mitochondrial degradation: Mitophagy and beyond

L Uoselis, TN Nguyen, M Lazarou - Molecular cell, 2023 - cell.com
Mitochondria are central hubs of cellular metabolism that also play key roles in signaling
and disease. It is therefore fundamentally important that mitochondrial quality and activity …

[HTML][HTML] Mitophagy in the retina: viewing mitochondrial homeostasis through a new lens

JI Jiménez-Loygorri, R Benítez-Fernández… - Progress in Retinal and …, 2023 - Elsevier
Mitochondrial function is key to support metabolism and homeostasis in the retina, an organ
that has one of the highest metabolic rates body-wide and is constantly exposed to …

Diversity of mitophagy pathways at a glance

IG Ganley, A Simonsen - Journal of Cell Science, 2022 - journals.biologists.com
Mitochondria are crucial organelles that play a central role in various cell signaling and
metabolic pathways. A healthy mitochondrial population is maintained through a series of …

Mitochondrial quality control in lung diseases: current research and future directions

J Liu, J Wang, A Xiong, L Zhang, Y Zhang, Y Liu… - Frontiers in …, 2023 - frontiersin.org
Lung diseases are a major global health problem, affecting millions of people worldwide.
Recent research has highlighted the critical role that mitochondrial quality control plays in …

Mitochondrial dysfunction associated with mtDNA in metabolic syndrome and obesity

N Todosenko, O Khaziakhmatova… - International Journal of …, 2023 - mdpi.com
Metabolic syndrome (MetS) is a precursor to the major health diseases associated with high
mortality in industrialized countries: cardiovascular disease and diabetes. An important …

The ubiquitin ligase TRIM32 promotes the autophagic response to Mycobacterium tuberculosis infection in macrophages

A Romagnoli, M Di Rienzo, E Petruccioli, C Fusco… - Cell Death & …, 2023 - nature.com
Mycobacterium tuberculosis (Mtb) is known to evade host immune responses and persist in
macrophages for long periods. A mechanism that the host uses to combat Mtb is xenophagy …

Role of AMBRA1 in mitophagy regulation: emerging evidence in aging-related diseases

M Di Rienzo, A Romagnoli, G Refolo, T Vescovo… - Autophagy, 2024 - Taylor & Francis
Aging is a gradual and irreversible physiological process that significantly increases the
risks of developing a variety of pathologies, including neurodegenerative, cardiovascular …

Mitophagy-associated programmed neuronal death and neuroinflammation

Y Zhu, J Zhang, Q Deng, X Chen - Frontiers in Immunology, 2024 - frontiersin.org
Mitochondria are crucial organelles that play a central role in cellular metabolism and
programmed cell death in eukaryotic cells. Mitochondrial autophagy (mitophagy) is a …

[HTML][HTML] The interplay between mitochondrial dynamics and autophagy: From a key homeostatic mechanism to a driver of pathology

A Lacombe, L Scorrano - Seminars in Cell & Developmental Biology, 2024 - Elsevier
The complex relationship between mitochondrial dynamics and autophagy illustrates how
two cellular housekeeping processes are intimately linked, illuminating fundamental …