Systematic review and meta-analysis of human genetic variants contributing to COVID-19 susceptibility and severity

K Gupta, G Kaur, T Pathak, I Banerjee - Gene, 2022 - Elsevier
The COVID-19 pandemic has spawned global health crisis of unprecedented magnitude,
claiming millions of lives and pushing healthcare systems in many countries to the brink …

The tryptophan catabolite or kynurenine pathway in COVID-19 and critical COVID-19: a systematic review and meta-analysis

AF Almulla, T Supasitthumrong… - BMC Infectious …, 2022 - Springer
Abstract Background Coronavirus disease 2019 (COVID-19) is accompanied by activated
immune-inflammatory pathways and oxidative stress, which both induce indoleamine-2, 3 …

SARS-CoV-2 drives NLRP3 inflammasome activation in human microglia through spike protein

EA Albornoz, AA Amarilla, N Modhiran, S Parker… - Molecular …, 2023 - nature.com
Abstract Coronavirus disease-2019 (COVID-19) is primarily a respiratory disease, however,
an increasing number of reports indicate that SARS-CoV-2 infection can also cause severe …

Lowered quality of life in long COVID is predicted by affective symptoms, chronic fatigue syndrome, inflammation and neuroimmunotoxic pathways

M Maes, HT Al-Rubaye, AF Almulla… - International journal of …, 2022 - mdpi.com
The physio-affective phenome of Long COVID-19 is predicted by (a) immune-inflammatory
biomarkers of the acute infectious phase, including peak body temperature (PBT) and …

Lowered oxygen saturation and increased body temperature in acute COVID-19 largely predict chronic fatigue syndrome and affective symptoms due to Long COVID …

DS Al-Hadrawi, HT Al-Rubaye, AF Almulla… - Acta …, 2023 - cambridge.org
Background: Long coronavirus disease 2019 (LC) is a chronic sequel of acute COVID-19.
The exact pathophysiology of the affective, chronic fatigue and physiosomatic symptoms …

Inflammation and oxidative stress in salt sensitive hypertension; The role of the NLRP3 inflammasome

LA Ertuglu, AP Mutchler, J Yu, A Kirabo - Frontiers in Physiology, 2022 - frontiersin.org
Salt-sensitivity of blood pressure is an independent risk factor for cardiovascular disease
and affects approximately half of the hypertensive population. While the precise …

Inflammasomes: a rising star on the horizon of COVID-19 pathophysiology

M Wang, F Yu, W Chang, Y Zhang, L Zhang… - Frontiers in …, 2023 - frontiersin.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a contagious respiratory
virus that is the cause of the coronavirus disease 2019 (COVID-19) pandemic which has …

NLRP3 inflammasome and interleukin-1 contributions to COVID-19-associated coagulopathy and immunothrombosis

N Potere, E Garrad, Y Kanthi, M Di Nisio… - Cardiovascular …, 2023 - academic.oup.com
Immunothrombosis—immune-mediated activation of coagulation—is protective against
pathogens, but excessive immunothrombosis can result in pathological thrombosis and …

Recent progress and prospects for anti-cytokine therapy in preclinical and clinical acute lung injury

GP Fadanni, JB Calixto - Cytokine & Growth Factor Reviews, 2023 - Elsevier
Acute respiratory distress syndrome (ARDS) is a heterogeneous cause of respiratory failure
that has a rapid onset, a high mortality rate, and for which there is no effective …

Ox-inflammasome involvement in neuroinflammation

A Vallese, V Cordone, A Pecorelli, G Valacchi - Free Radical Biology and …, 2023 - Elsevier
Neuroinflammation plays a crucial role in the onset and the progression of several
neuropathologies, from neurodegenerative disorders to migraine, from Rett syndrome to …