Liquid–liquid phase separation in tumor biology

X Tong, R Tang, J Xu, W Wang, Y Zhao, X Yu… - Signal Transduction and …, 2022 - nature.com
Liquid–liquid phase separation (LLPS) is a novel principle for explaining the precise spatial
and temporal regulation in living cells. LLPS compartmentalizes proteins and nucleic acids …

Exploring the mechanical perspective of a new anti-tumor agent: melatonin

S Rohilla, M Singh, S Priya, WH Almalki… - Journal of …, 2023 - dl.begellhouse.com
Melatonin is a serotonin-derived pineal gland hormone with many biological functions like
regulating the sleep-wake cycle, circadian rhythm, menstrual cycle, aging, immunity, and …

Understanding the mechanism of action of melatonin, which induces ROS production in cancer cells

J Florido, C Rodriguez-Santana, L Martinez-Ruiz… - Antioxidants, 2022 - mdpi.com
Reactive oxygen species (ROS) constitute a group of highly reactive molecules that have
evolved as regulators of important signaling pathways. In this context, tumor cells have an …

Aging-related ovarian failure and infertility: melatonin to the rescue

RJ Reiter, R Sharma, A Romero, W Manucha, DX Tan… - Antioxidants, 2023 - mdpi.com
Aging has a major detrimental effect on the optimal function of the ovary with changes in this
organ preceding the age-related deterioration in other tissues, with the middle-aged …

Melatonin from microorganisms, algae, and plants as possible alternatives to synthetic melatonin

MB Arnao, M Giraldo-Acosta, A Castejón-Castillejo… - Metabolites, 2023 - mdpi.com
Melatonin dietary supplements are widely consumed worldwide, with developed countries
as the largest consumers, with an estimated annual growth rate of approximately 10% until …

Phase separation in cancer at a glance

Q Xie, J Cheng, W Mei, D Yang, P Zhang… - Journal of Translational …, 2023 - Springer
Eukaryotic cells are segmented into multiple compartments or organelles within the cell that
regulate distinct chemical and biological processes. Membrane-less organelles are …

Prion therapeutics: Lessons from the past

KH Shim, N Sharma, SSA An - Prion, 2022 - Taylor & Francis
Prion diseases are a group of incurable zoonotic neurodegenerative diseases (NDDs) in
humans and other animals caused by the prion proteins. The abnormal folding and …

Melatonin: Regulation of viral phase separation and Epitranscriptomics in post-acute sequelae of COVID-19

D Loh, RJ Reiter - International journal of molecular sciences, 2022 - mdpi.com
The relentless, protracted evolution of the SARS-CoV-2 virus imposes tremendous pressure
on herd immunity and demands versatile adaptations by the human host genome to counter …

How gallic acid regulates molecular signaling: role in cancer drug resistance

S Hassani, F Ghanbari, M Lotfi, W Alam, M Aschner… - Medical Oncology, 2023 - Springer
Cancer is one of the deadliest and most heterogeneous diseases. Cancers often develop
drug resistance, which can lead to treatment failure or recurrence. Accordingly, anticancer …

Melatonin regulates cancer migration and stemness and enhances the anti‐tumour effect of cisplatin

L Cheng, S Li, K He, Y Kang, T Li, C Li… - Journal of cellular …, 2023 - Wiley Online Library
Melatonin, a lipophilic hormone released from the pineal gland, has oncostatic effects on
various types of cancers. However, its cancer treatment potential needs to be improved by …