Intervertebral disc degeneration (IVDD) is a pathological condition that can lead to
intractable back pain or secondary neurological deficits. There is no fundamental cure for …

Mesenchymal stem cells (MSCs) are multipotent cells that show self-renewal, multi-
directional differentiation, and paracrine and immune regulation. As a result of these …

Background Enhanced angiogenesis can promote diabetic wound healing. Mesenchymal
stem cells (MSCs)-derived exosomes, which are cell-free therapeutics, are promising …

Diabetes mellitus is one of the most common metabolic diseases in the developed world,
and is associated either with the impaired secretion of insulin or with the resistance of cells …

Intervertebral disc degeneration (IDD), characterized as decreased proteoglycan content,
ossification of endplate, and decreased intervertebral height, is one of the major reasons of …

Tissue specificity, a key factor in the decellularized tissue matrix (DTM), has shown bioactive
functionalities in tuning cell fate—eg, the differentiation of mesenchymal stem cells. Notably …

Intervertebral disc degeneration (IVDD) is a common musculoskeletal degenerative disease
worldwide, of which the main clinical manifestation is low back pain (LBP); approximately …

The intervertebral disc (IVD) is a complex tissue, and its degeneration remains a problem for
patients, without significant improvement in treatment strategies. This mostly age-related …

Oxidative stress is relevant in compression‐induced nucleus pulposus (NP) cell apoptosis
and intervertebral disc (IVD) degeneration. Exosomes derived from bone mesenchymal …

Low back pain is a vital musculoskeletal disease that impairs life quality, leads to disability
and imposes heavy economic burden on the society, while it is greatly attributed to …