CD4+ T cells differentiate and acquire distinct functions to combat specific pathogens but
can also adapt their functions in response to changing circumstances. Although this …

Abstract Interleukin-2 (IL-2) and its receptor (IL-2R) are essential in orchestrating immune
responses. Their function and expression in the tumor microenvironment make them …

Regulatory T (TReg) cells are crucial for the prevention of fatal autoimmunity in mice and
humans. Forkhead box P3 (FOXP3)+ TReg cells are produced in the thymus and are also …

Regulatory T cells (Treg cells) are required for immune homeostasis. Chromatin remodeling
is essential for establishing diverse cellular identities, but how the epigenetic program in …

Several lines of evidence indicate the instability of CD4+ Foxp3+ regulatory T cells (Tregs).
We have therefore investigated means of promoting the stability of Tregs. In this study, we …

Dendritic cells (DC) are antigen-presenting cells that can communicate with T cells both
directly and indirectly, regulating our adaptive immune responses against environmental …

Regulatory T cells (Tregs) prevent autoimmunity and tissue damage resulting from
excessive or unnecessary immune activation through their suppressive function. While their …

During homeostasis, interactions between tolerogenic dendritic cells (DCs), self-reactive T
cells, and T regulatory cells (Tregs) contribute to maintaining mammalian immune tolerance …

CD4+ CD25+ regulatory T (Treg) cells play a pivotal role in the maintenance of immune
homeostasis, where the X-linked master transcription factor forkhead box P3 (FOXP3) …

We recognize well the abilities of dendritic cells to activate effector T cell (Teff cell)
responses to an array of antigens and think of these cells in this context as pre-eminent …