T cell responses to SARS-CoV-2

A Sette, J Sidney, S Crotty - Annual review of immunology, 2023 - annualreviews.org
A large body of evidence generated in the last two and a half years addresses the roles of T
cells in SARS-CoV-2 infection and following vaccination. Infection or vaccination induces …

The T cell immune response against SARS-CoV-2

P Moss - Nature immunology, 2022 - nature.com
The adaptive immune response is a major determinant of the clinical outcome after SARS-
CoV-2 infection and underpins vaccine efficacy. T cell responses develop early and …

COVID-19 mRNA vaccines: Platforms and current developments

GT Szabó, AJ Mahiny, I Vlatkovic - Molecular Therapy, 2022 - cell.com
Since the first successful application of messenger ribonucleic acid (mRNA) as a vaccine
agent in a preclinical study nearly 30 years ago, numerous advances have been made in …

SARS-CoV-2-specific T cells in the changing landscape of the COVID-19 pandemic

A Bertoletti, N Le Bert, AT Tan - Immunity, 2022 - cell.com
Since the onset of the coronavirus disease 2019 (COVID-19) pandemic, multiple severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants with increasing ability to …

[HTML][HTML] SARS-CoV-2 breakthrough infection in vaccinees induces virus-specific nasal-resident CD8+ and CD4+ T cells of broad specificity

JME Lim, AT Tan, N Le Bert, SK Hang… - Journal of Experimental …, 2022 - rupress.org
SARS-CoV-2 breakthrough infection in vaccinees induces virus-specific nasal-resident CD8+
and CD4+ T cells of broad specificity | Journal of Experimental Medicine | Rockefeller …

Advances and utility of the human plasma proteome

EW Deutsch, GS Omenn, Z Sun, M Maes… - Journal of proteome …, 2021 - ACS Publications
The study of proteins circulating in blood offers tremendous opportunities to diagnose,
stratify, or possibly prevent diseases. With recent technological advances and the urgent …

SARS-CoV-2 accessory proteins ORF7a and ORF3a use distinct mechanisms to down-regulate MHC-I surface expression

N Arshad, M Laurent-Rolle… - Proceedings of the …, 2023 - National Acad Sciences
Major histocompatibility complex class I (MHC-I) molecules, which are dimers of a
glycosylated polymorphic transmembrane heavy chain and the small-protein β2 …

The T-cell-directed vaccine BNT162b4 encoding conserved non-spike antigens protects animals from severe SARS-CoV-2 infection

CM Arieta, YJ Xie, DA Rothenberg, H Diao, D Harjanto… - Cell, 2023 - cell.com
T cell responses play an important role in protection against beta-coronavirus infections,
including SARS-CoV-2, where they associate with decreased COVID-19 disease severity …

Allelic variation in class I HLA determines CD8+ T cell repertoire shape and cross-reactive memory responses to SARS-CoV-2

JM Francis, D Leistritz-Edwards, A Dunn, C Tarr… - Science …, 2021 - science.org
Effective presentation of antigens by human leukocyte antigen (HLA) class I molecules to
CD8+ T cells is required for viral elimination and generation of long-term immunological …

A streamlined platform for analyzing tera-scale DDA and DIA mass spectrometry data enables highly sensitive immunopeptidomics

L Xin, R Qiao, X Chen, H Tran, S Pan… - Nature …, 2022 - nature.com
Integrating data-dependent acquisition (DDA) and data-independent acquisition (DIA)
approaches can enable highly sensitive mass spectrometry, especially for …