Hyperpolarization-activated, cyclic nucleotide–gated (HCN) channels are important
members of the voltage-gated pore loop channels family. They show unique features: they …

Epilepsy is the most common chronic neurological disease, affecting about 1% of the world's
population during their lifetime. Most people with epilepsy can attain a seizure-free life upon …

Hyperpolarization-activated, cyclic nucleotide-gated (HCN) channels, the molecular
correlate of the hyperpolarization-activated current (If/Ih), are membrane proteins which play …

Background and Purpose Natural flavonoids are ubiquitous in dietary plants and vegetables
and have been proposed to have antiviral, antioxidant, cardiovascular protective and …

Plant voltage-gated K+ channels have been referred to as “plant Shakers” in reference to
animal Shaker channels, the first K+ channels identified. Recent advances in our knowledge …

Hyperpolarization-activated cyclic nucleotide-gated (HCN) ion channels play an important
role in regulating electrical activity in the heart and brain. They are gated by the binding of …

SK, HCN, and M channels are medium afterhyperpolarization (mAHP)-mediating ion
channels. The three channels co-express in various brain regions, and their collective action …

Firing activity of external globus pallidus (GPe) is crucial for motor control and is severely
perturbed in dystonia, a movement disorder characterized by involuntary, repetitive muscle …

There is an increasing interest in the biological and therapeutic effects of fisetin, a natural
phenolic compound. Fisetin has affinity on some neuronal targets and may have the …

Cannabidiol (CBD), the main non-psychotropic phytocannabinoid produced by the
Cannabis sativa plant, blocks a variety of cardiac ion channels. We aimed to identify whether …