High-density lipoprotein revisited: biological functions and clinical relevance

A von Eckardstein, BG Nordestgaard… - European heart …, 2023 - academic.oup.com
Previous interest in high-density lipoproteins (HDLs) focused on their possible protective
role in atherosclerotic cardiovascular disease (ASCVD). Evidence from genetic studies and …

[HTML][HTML] Leveraging knowledge of HDLs major protein ApoA1: Structure, function, mutations, and potential therapeutics

AS Bhale, K Venkataraman - Biomedicine & Pharmacotherapy, 2022 - Elsevier
Abstract Apolipoprotein A1 (ApoA1) is a member of the Apolipoprotein family of proteins. It's
a vital protein that helps in the production of high-density lipoprotein (HDL) particles, which …

Human cerebrospinal fluid contains diverse lipoprotein subspecies enriched in proteins implicated in central nervous system health

NJ Merrill, WS Davidson, Y He, I Díaz Ludovico… - Science …, 2023 - science.org
Lipoproteins in cerebrospinal fluid (CSF) of the central nervous system (CNS) resemble
plasma high-density lipoproteins (HDLs), which are a compositionally and structurally …

HDL functions—current status and future perspectives

Y Endo, M Fujita, K Ikewaki - Biomolecules, 2023 - mdpi.com
Cardiovascular disease (CVD) is the leading cause of death in Western countries. A low
HDL-C is associated with the development of CVD. However, recent epidemiology studies …

Sex-specific differences in lipoprotein production and clearance

DM Conlon, FK Welty, G Reyes-Soffer… - … , and vascular biology, 2023 - Am Heart Assoc
Therapeutic approaches to reduce atherogenic lipid and lipoprotein levels remain the most
effective and assessable strategies to prevent and treat cardiovascular disease. The …

Dyslipidemia in rheumatoid arthritis: the possible mechanisms

J Yan, S Yang, L Han, X Ba, P Shen, W Lin… - Frontiers in …, 2023 - frontiersin.org
Rheumatoid arthritis (RA) is an autoimmune inflammatory disease, of which the leading
cause of death is cardiovascular disease (CVD). The levels of total cholesterol (TC), low …

Preeclampsia affects lipid metabolism and HDL function in mothers and their offspring

JT Stadler, H Scharnagl, C Wadsack, G Marsche - Antioxidants, 2023 - mdpi.com
Preeclampsia (PE) is linked to an overall increased cardiovascular risk for both the mother
and child. Functional impairment of high-density lipoproteins (HDL) may contribute to the …

Emerging role of HDL in brain cholesterol metabolism and neurodegenerative disorders

M Turri, C Marchi, MP Adorni, L Calabresi… - Biochimica et Biophysica …, 2022 - Elsevier
High-density lipoproteins (HDL) play a key role in cholesterol homeostasis maintenance in
the central nervous system (CNS), by carrying newly synthesized cholesterol from astrocytes …

Novel Size‐Based High‐Density Lipoprotein Subspecies and Incident Vascular Events

A Deets, PH Joshi, A Chandra, K Singh… - Journal of the …, 2023 - Am Heart Assoc
Background High‐density lipoprotein (HDL) particle concentration likely outperforms HDL
cholesterol in predicting atherosclerotic cardiovascular events. Whether size‐based HDL …

Inflammation and oxidative stress induced by obesity, gestational diabetes, and preeclampsia in pregnancy: role of high-density lipoproteins as vectors for bioactive …

AS Jiménez-Osorio, E Carreón-Torres, E Correa-Solís… - Antioxidants, 2023 - mdpi.com
Inflammation and oxidative stress are essential components in a myriad of pathogenic
entities that lead to metabolic and chronic diseases. Moreover, inflammation in its different …