Targeting purinergic pathway to enhance radiotherapy-induced immunogenic cancer cell death

X Bao, L Xie - Journal of Experimental & Clinical Cancer Research, 2022 - Springer
Emerging evidence has demonstrated that radiotherapy (RT) can not only cause direct
damage to cancer cells but also lead to immunogenic cell death (ICD), which involves the …

[HTML][HTML] Cancer stem cell-targeted chimeric antigen receptor (CAR)-T cell therapy: Challenges and prospects

J Masoumi, A Jafarzadeh, J Abdolalizadeh… - … Pharmaceutica Sinica B, 2021 - Elsevier
Cancer stem cells (CSCs) with their self-renewal ability are accepted as cells which initiate
tumors. CSCs are regarded as interesting targets for novel anticancer therapeutic agents …

Platelet-membrane-camouflaged bismuth sulfide nanorods for synergistic radio-photothermal therapy against cancer

Y Chen, G Zhao, S Wang, Y He, S Han, C Du, S Li… - Biomaterials …, 2019 - pubs.rsc.org
Bismuth-containing nanoparticles (BNPs) are potential enhancers for tumor radiotherapy.
Improving the bioavailability and developing synergistic therapeutic regimens benefit the …

Endoglin targeting: lessons learned and questions that remain

Y Liu, M Paauwe, AB Nixon… - International journal of …, 2020 - mdpi.com
Approximately 30 years ago, endoglin was identified as a transforming growth factor (TGF)-β
coreceptor with a crucial role in developmental biology and tumor angiogenesis. Its …

Role of endoglin (CD105) in the progression of hepatocellular carcinoma and anti-angiogenic therapy

A Kasprzak, A Adamek - International Journal of Molecular Sciences, 2018 - mdpi.com
The liver is perfused by both arterial and venous blood, with a resulting abnormal
microenvironment selecting for more-aggressive malignancies. Hepatocellular carcinoma …

[HTML][HTML] Molecular Sentinels: Unveiling the Role of Sirtuins in Prostate Cancer Progression

S Chouhan, N Muhammad, D Usmani… - International Journal of …, 2024 - mdpi.com
Prostate cancer (PCa) remains a critical global health challenge, with high mortality rates
and significant heterogeneity, particularly in advanced stages. While early-stage PCa is …

Endoglin in the spotlight to treat cancer

T González Muñoz, AT Amaral… - International Journal of …, 2021 - mdpi.com
A spotlight has been shone on endoglin in recent years due to that fact of its potential to
serve as both a reliable disease biomarker and a therapeutic target. Indeed, endoglin has …

CD105: tumor diagnosis, prognostic marker and future tumor therapeutic target

L Li, L Zhong, C Tang, L Gan, T Mo, J Na, J He… - Clinical and …, 2022 - Springer
Cancer is one of the diseases with the highest morbidity and mortality rates worldwide, and
its therapeutic options are inadequate. The endothelial glycoprotein, also known as CD105 …

Immunotargeting of cancer stem cells

AS Köseer, S Di Gaetano, C Arndt, M Bachmann… - Cancers, 2023 - mdpi.com
Simple Summary Tumor cells from the same specimen are functionally heterogeneous.
Cancer stem cells (CSCs) are populations of tumor cells with self-renewal and differentiation …

HDAC2 inhibitor valproic acid increases radiation sensitivity of drug-resistant melanoma cells

BS Kalal, VR Pai, SK Behera, HM Somashekarappa - Medical Sciences, 2019 - mdpi.com
Resistance to anticancer drugs limits the effectiveness of chemotherapy in cancers.
Melanoma cell lines B16F10C and A375C (parental) and B16F10R and A375R (drug …