Antibiotic resistance and infections caused by multidrug-resistant bacteria are global health
concerns. Reducing the overuse and misuse of antibiotics is the primary step toward …

The clinical application of quinolone antibiotics is particularly extensive. In addition to their
high efficiency in infectious diseases, the treatment process brings multiple hidden dangers …

Understanding how bactericidal antibiotics kill bacteria remains an open question. Previous
work has proposed that primary drug-target corruption leads to increased energetic …

Pathogenic bacteria are the leading causes of food-borne and water-borne infections, and
one of the most serious public threats. Traditional bacterial detection techniques, including …

Quinolones are a type of bicyclic privileged building block with immense therapeutic
potential. They are known for their crucial role in modulating numerous diseases conditions …

Moxifloxacin is central to treatment of multidrug-resistant tuberculosis. Effects of moxifloxacin
on the Mycobacterium tuberculosis redox state were explored to identify strategies for …

In light of the antibiotic crisis, emerging strategies to sensitize bacteria to available
antibiotics should be explored. Several studies on the mechanisms of killing suggest that …

Antibiotic resistance in bacteria has remained a serious public health concern, resulting in
substantial deaths and morbidity each year. Factors such as mutation and abuse of currently …

The increasing emergence of multidrug-resistant (MDR) pathogens causes difficult-to-treat
infections with long-term hospitalizations and a high incidence of death, thus representing a …

Purpose Tuberculosis (TB) is a chronic disease caused by Mycobacterium tuberculosis
(MTB) that remains a major global health challenge. One of the main obstacles to effective …