Congenital adrenal hyperplasia (CAH) is a group of autosomal recessive disorders affecting
cortisol biosynthesis. Reduced activity of an enzyme required for cortisol production leads to …

Many oxidation–reduction (redox) enzymes, particularly oxygenases, have roles in reactions
that make and break C–C bonds. The list includes cytochrome P450 and other heme-based …

BACKGROUND Non-classic congenital hyperplasia (NCAH) due to 21-hydroxylase
deficiency is a common autosomal recessive disorder characterized by androgen excess …

Objective To comprehensively characterize androgens and androgen precursors in classic
21-hydroxylase deficiency (21OHD) and to gain insights into the mechanisms of their …

This review provides the reader with current insights on testicular adrenal rest tumors
(TARTs), a complication in male patients with congenital adrenal hyperplasia (CAH). In …

The congenital adrenal hyperplasias comprise a family of autosomal recessive disorders
that disrupt adrenal steroidogenesis. The most common form is due to 21-hydroxylase …

Objective Whether serum androgen levels can identify women with “androgen insufficiency”
or “androgen excess” is unresolved; thus, what constitutes “normal” remains uncertain. We …

The abundant adrenal C19 steroid 11β-hydroxyandrostenedione (11OHA4) has been
written off as a dead-end product of adrenal steroidogenesis. However, recent evidence has …

Congenital adrenal hyperplasia (CAH) caused by 21‐hydroxylase deficiency accounts for
95% of all CAH cases and is one of the most common inborn metabolic conditions. The …

Context The ovaries and adrenals are sources of androgens in women. Although
dehydroepiandrosterone (DHEA), DHEA sulfate (DHEAS), and testosterone (T) all decline …