Uncovering the genetic and evolutionary basis of local adaptation is a major focus of
evolutionary biology. The recent development of cost-effective methods for obtaining high …

Dissecting the genetic architecture of complex traits is an ongoing challenge for geneticists.
Two complementary approaches for genetic mapping, linkage mapping and association …

A 1000-cow study across four European countries was undertaken to understand to what
extent ruminant microbiomes can be controlled by the host animal and to identify …

INTRODUCTION Variation in pigmentation among human populations may reflect local
adaptation to regional light environments, because dark skin is more photoprotective …

Population structure causes genome-wide linkage disequilibrium between unlinked loci,
leading to statistical confounding in genome-wide association studies. Mixed models have …

We describe factored spectrally transformed linear mixed models (FaST-LMM), an algorithm
for genome-wide association studies (GWAS) that scales linearly with cohort size in both run …

Microarray expression studies suffer from the problem of batch effects and other unwanted
variation. Many methods have been proposed to adjust microarray data to mitigate the …

Genome‐wide association studies (GWAS) are widely used in diploid species to study
complex traits in diversity and breeding populations, but GWAS software tailored to …

Early application of genomic selection relied on SNP estimation with phenotypes or de-
regressed proofs (DRP). Chips of 50k SNP seemed sufficient for an accurate estimation of …

Goat domestication was critical for agriculture and civilization, but its underlying genetic
changes and selection regimes remain unclear. Here, we analyze the genomes of …