Lipoxygenases (LOXs) form a heterogeneous class of lipid peroxidizing enzymes, which
have been implicated not only in cell proliferation and differentiation but also in the …

Upon blood vessel injury, platelets are exposed to adhesive proteins in the vascular wall
and soluble agonists, which initiate platelet activation, leading to formation of hemostatic …

Polyunsaturated fatty acids (PUFAs) are structural components of membrane phospholipids
in cells. PUFAs regulate cellular function through the formation of derived lipid mediators …

Arachidonic acid can be oxygenated by a variety of different enzymes, including
lipoxygenases, cyclooxygenases, and cytochrome P450s, and can be converted to a …

Cancer and inflammation are intimately linked due to specific oxidative processes in the
tumor microenvironment. Lipoxygenases are a versatile class of oxidative enzymes involved …

Severe acute respiratory syndrome coronavirus (SARS-CoV-2) infection leads to the
development of coronavirus disease 2019 (COVID-19), which causes endothelial …

Classical proinflammatory eicosanoids, and more recently discovered lipid mediators with
anti-inflammatory and proresolving bioactivity, exert a complex role in the initiation, control …

Platelet ACKR3/CXCR7 surface expression is enhanced and influences prognosis in
coronary artery disease (CAD) patients, who exhibit a distinct atherothrombotic platelet …

Oxylipins, the oxidation products of unsaturated fatty acids (FA), are potent endogenous
mediators being involved in the regulation of various biological processes such as …

Cystic fibrosis (CF) is the most common genetic disorder among Caucasians, estimated to
affect more than 70,000 people in the world. Severe and persistent bronchial inflammation …