Endoplasmic reticulum stress and lipids in health and diseases
The endoplasmic reticulum (ER) is a complex and dynamic organelle that regulates many
cellular pathways, including protein synthesis, protein quality control, and lipid synthesis …
cellular pathways, including protein synthesis, protein quality control, and lipid synthesis …
Endoplasmic reticulum stress as a therapeutic target in cardiovascular disease
T Minamino, I Komuro, M Kitakaze - Circulation research, 2010 - Am Heart Assoc
Cardiovascular disease constitutes a major and increasing health burden in developed
countries. Although treatments have progressed, the development of novel treatments for …
countries. Although treatments have progressed, the development of novel treatments for …
From acute ER stress to physiological roles of the unfolded protein response
J Wu, RJ Kaufman - Cell Death & Differentiation, 2006 - nature.com
When protein folding in the endoplasmic reticulum (ER) is disrupted by alterations in
homeostasis in the ER lumen, eucaryotic cells activate a series of signal transduction …
homeostasis in the ER lumen, eucaryotic cells activate a series of signal transduction …
Endoplasmic reticulum stress activates cleavage of CREBH to induce a systemic inflammatory response
Regulated intramembrane proteolysis (RIP) of endoplasmic reticulum (ER) membrane-
anchored transcription factors is known to maintain sterol homeostasis and to mediate the …
anchored transcription factors is known to maintain sterol homeostasis and to mediate the …
The endoplasmic reticulum stress response in immunity and autoimmunity
DJ Todd, AH Lee, LH Glimcher - Nature reviews immunology, 2008 - nature.com
Many exogenous sources of stress can lead to cell death. In recent years, endogenous
cellular sources of stress have also been identified, including the stress that arises from the …
cellular sources of stress have also been identified, including the stress that arises from the …
Endoplasmic reticulum stress: signaling the unfolded protein response
E Lai, T Teodoro, A Volchuk - Physiology, 2007 - journals.physiology.org
The endoplasmic reticulum (ER) is the cellular site of newly synthesized secretory and
membrane proteins. Such proteins must be properly folded and posttranslationally modified …
membrane proteins. Such proteins must be properly folded and posttranslationally modified …
Intracellular signaling by the unfolded protein response
S Bernales, FR Papa, P Walter - Annu. Rev. Cell Dev. Biol., 2006 - annualreviews.org
The unfolded protein response (UPR) is an intracellular signaling pathway that is activated
by the accumulation of unfolded proteins in the endoplasmic reticulum (ER). UPR activation …
by the accumulation of unfolded proteins in the endoplasmic reticulum (ER). UPR activation …
Classification of human B-ZIP proteins based on dimerization properties
C Vinson, M Myakishev, A Acharya, AA Mir… - … and cellular biology, 2002 - Am Soc Microbiol
BACKGROUND In the late 1980s, several mammalian B-ZIP proteins were purified by
double-stranded DNA affinity chromatography, and the genes encoding these proteins were …
double-stranded DNA affinity chromatography, and the genes encoding these proteins were …
CREB3 transcription factors: ER-golgi stress transducers as hubs for cellular homeostasis
L Sampieri, P Di Giusto, C Alvarez - Frontiers in cell and …, 2019 - frontiersin.org
CREB3 family of transcription factors are ER localized proteins that belong to the bZIP
family. They are transported from the ER to the Golgi, cleaved by S1P and S2P proteases …
family. They are transported from the ER to the Golgi, cleaved by S1P and S2P proteases …
Update on the molecular biology of dyslipidemias
I Ramasamy - Clinica chimica acta, 2016 - Elsevier
Dyslipidemia is a commonly encountered clinical condition and is an important determinant
of cardiovascular disease. Although secondary factors play a role in clinical expression …
of cardiovascular disease. Although secondary factors play a role in clinical expression …