Migraine is a neurological ailment that is characterized by severe throbbing unilateral
headache and associated with nausea, photophobia, phonophobia and vomiting. A full and …

Targeting CGRP has proved to be efficacious, tolerable, and safe to treat migraine; however,
many patients with migraine do not benefit from drugs that antagonize the CGRPergic …

The indole scaffold probably represents one of the most important structural subunits for the
discovery of new drug candidates. The demonstration that many alkaloids contain the indole …

Chronic itch is a prevalent and debilitating condition for which few effective therapies are
available. We harnessed the natural variation across genetically distinct mouse strains to …

Psychedelics are quite unique among drugs that impact the central nervous system, as a
single administration of a psychedelic can both rapidly alter subjective experience in …

Background Irritable bowel syndrome (IBS) is a functional disorder of the gastrointestinal
tract characterized by abdominal discomfort, pain and changes in bowel habits, often …

After 35 years since the introduction of the International Classification of Headache
Disorders (ICHD), we are living in the era of the second great revolution in migraine …

The pivotal role of calcitonin gene-related peptide (CGRP) in migraine pathophysiology was
identified over 30 years ago, but the successful clinical development of targeted therapies …

Background Migraine is a complex, multifaceted, and disabling headache disease that is
often complicated by gastrointestinal (GI) conditions, such as gastroparesis, functional …

Migraine is a chronic, recurrent, disabling condition that affects millions of people in the US
and worldwide. Proper acute care treatment for migraineurs is essential for a full return of …