Sickle cell nephropathy is a major complication of sickle cell disease. It manifests in different
forms, including glomerulopathy, proteinuria, hematuria, and tubular defects, and frequently …

Background Sickle cell disease (SCD) is a diverse group of blood disorders with significant
global disease burden. Contemporary interest in the underlying inflammatory paradigm of …

Background: Sickle cell anaemia (SCA) imposes a substantial healthcare burden, affecting
millions of people worldwide. Understanding the determinants influencing SCA severity is …

The renal functions and structure in sickle cell anaemia (SCA) patients may be affected by
chronic haemodynamic changes and consequences of vaso-occlusive events in the renal …

BACKGROUND: Neutrophil-lymphocyte ratio (NLR) and Platelet-Lymphocyte ratio (PLR) are
emerging markers of systemic inflammation in chronic disorders, including …

Sickle cell nephopathy (SCN) begins early in childhood from failure of urinary concentration
(hyposthenuria), albuminuria to hyperfiltration, hematuria and progression to falling …

Background: Sickle cell disease is a monogenetic disorder resulting in early mortality and
widespread organ damage, including pulmonary, cardiac, and splenic dysfunction, as well …

Abstract Sickle Cell Disease (SCD) is a hereditary hemoglobinopathy characterized by
chronic hemolytic anemia and vaso-occlusive events. In recent years, the Neutrophil-to …

Objective: Proteinuria is associated with inflammation, endothelial dysfunction, platelet
activation, and progression of kidney disease. The biological mechanisms by which …

Introduction-Sickle cell disease has long been recognized as an inflammatory condition and
oxidative stress play an important role in pathophysiology of SCD. Several biomarkers have …