Speckle-type BTB/POZ protein (SPOP) is a substrate recognition receptor of the cullin-3
(CUL3)/RING type ubiquitin E3 complex. To date, approximately 30 proteins have been …

Simple Summary Prostate cancer is one of the most common and lethal tumors in men
worldwide. Due to the high heterogeneity of the disease, the optimal treatment choice for …

In the last years, extensive investigation on miRNomics have shown to have great
advantages in cancer personalized medicine regarding diagnosis, treatment and even …

There is an urgent need for markers to predict the efficacy of different chemotherapy drugs.
Herein, we examined whether microsatellite instability (MSI) status can predict tumor …

MicroRNA (miRNA) modulation has been identified as a promising strategy for improving the
response of human prostate cancer (PCa) to radiotherapy (RT). Studies have shown that …

In this paper, we first synthesis three-dimensional jasmine-like Cu@ L-aspartic acid (L-ASP)
inorganic–organic hybrid nanoflowers to load palladium-platinum nanoparticles (Pd–Pt …

Proteasomal degradation is an essential regulatory mechanism for cellular homeostasis
maintenance. The speckle-type POZ adaptor protein (SPOP) is part of the ubiquitin ligase E3 …

PCa is the most common male cancer in Germany and the second leading cause of male
cancer deaths. Genomic instability and DNA repair defects are considered hallmarks of PCa …

In this paper, we rst synthesis three-dimensional (3D) jasmine-like Cu@ L-Asp inorganic-
organic hybrid nano owers to load palladium-platinum nanoparticles as the signal enhancer …

SPOP is an adaptor subunit of Cullin3-RING E3 ubiquitin ligase complexes that plays a key
role in maintenance of cellular homeostasis through its interactions with other proteins …