Reagents that bind tightly and specifically to biomolecules of interest remain essential in the exploration of biology and in their ultimate application to medicine. Besides ligands for …
H Ho, A Miu, MK Alexander, NK Garcia, A Oh… - Nature, 2018 - nature.com
The movement of core-lipopolysaccharide across the inner membrane of Gram-negative bacteria is catalysed by an essential ATP-binding cassette transporter, MsbA. Recent …
G protein-coupled receptors (GPCRs) activate heterotrimeric G proteins by mediating a GDP to GTP exchange in the Gα subunit. This leads to dissociation of the heterotrimer into Gα …
KA Henry, CR MacKenzie - MAbs, 2018 - Taylor & Francis
ABSTRACT Single-domain antibodies (sdAbs), the autonomous variable domains of heavy chain-only antibodies produced naturally by camelid ungulates and cartilaginous fishes …
S Srikant, R Gaudet - Nature structural & molecular biology, 2019 - nature.com
Much structural information has been amassed on ATP-binding cassette (ABC) transporters, including hundreds of structures of isolated domains and an increasing array of full-length …
Cellular membranes are highly dynamic in shape. They can rapidly and precisely regulate their shape to perform various cellular functions. The protein's ability to sense membrane …
ABC exporters harness the energy of ATP to pump substrates across membranes. Extracellular gate opening and closure are key steps of the transport cycle, but the …
AS Ramírez, KP Locher - Glycobiology, 2023 - academic.oup.com
N-linked protein glycosylation is a post-translational modification that exists in all domains of life. It involves two consecutive steps:(i) biosynthesis of a lipid-linked oligosaccharide (LLO) …
ABCG2 is an ATP-binding cassette transporter that exports a wide range of xenobiotic compounds and has been recognized as a contributing factor for multidrug resistance in …