The dramatic recent advances in molecular biology, which have opened a new era in
medicine and biotechnology, rely on improved techniques to study large molecules …

This review describes the electrophoresis of curved and normal DNA molecules in agarose
gels, polyacrylamide gels and in free solution. These studies were undertaken to clarify why …

The pore size of agarose gel in water at different concentrations was directly measured
using atomic force microscopy (AFM). The experiment was specially designed to work under …

Using a multitechnique approach, two temperature domains have been identified in agarose
gelation. Below 35° C, fast gelation results in strong, homogeneous and weakly turbid …

The mobilities of various DNA fragments in two normally migrating molecular weight ladders
were studied in polyacrylamide gels containing different concentrations of the crosslinker N …

Using capillary electrophoresis, large DNA molecules (2.0–23.1 kbp) may be rapidly
separated in ultradilute polymer solutions (< 0.002% w/w) under, a high‐voltage, steady field …

Long, accurate reads are an important factor for high-throughput de novo DNA sequencing.
In previous work from this laboratory, a separation matrix of high-weight-average molecular …

Electrophoresis of DNA through gels of agarose or polyacrylamide (PA) has been one of the
most widely used techniques of molecular biology during the past decade, serving both …

DNA electrophoretic mobilities are highly dependent on the nature of the matrix in which the
separation takes place. This review describes the effect of the matrix on DNA separations in …

The read length for DNA sequencing using capillary electrophoresis and replaceable linear
polyacrylamide (LPA) solutions has been extended to more than 1000 bases with a run time …