Synthesis de novo, acquisition by salvage and interconversion of purines and pyrimidines
represent the fundamental requirements for their eventual assembly into nucleic acids as …

Malaria is a major vector-borne disease in India. Based on vast geographic areas with
associated topographic and climatic diversity, the variable malaria epidemiology in India is …

Interactions between mutations (epistasis) can add substantial complexity to genotype-
phenotype maps, hampering our ability to predict evolution. Yet, recent studies have shown …

The adaptive landscape analogy has found practical use in recent years, as many have
explored how their understanding can inform therapeutic strategies that subvert the …

Antimalarial drug resistance is a major global challenge in malaria control and elimination.
Mutations in six different genes of Plasmodium falciparum (crt, mdr1, dhfr, dhps, ATPase6 …

North-east India, being a corridor to South-east Asia, is believed to play an important role in
transmitting drug resistant Plasmodium falciparum malaria to India and South Asia. North …

Malaria, a leading parasitic disease, inflicts an enormous toll on human lives and is caused
by protozoal parasites belonging to the genus Plasmodium. Antimalarial drugs targeting …

The antifolate drugs sulfadoxine and pyrimethamine are commonly used to treat
Plasmodium falciparum malaria. However, they can also affect the Plasmodium vivax …

With the spread of chloroquine (CQ)-resistant malaria in India, sulfadoxine-pyrimethamine
(SP) alone or in combination with artesunate is used as an alternative antimalarial drug. Due …

Treatment of Plasmodium falciparum is complicated by the emergence and spread of
parasite resistance to many of the first-line drugs used to treat malaria. Antimalarial drug …