The demand for an efficient therapy for alopecia disease has fueled the hair research field in
recent decades. However, despite significant improvements in the knowledge of key …

CD49f (integrin subunit α6) regulates signaling pathways in a variety of cellular activities.
However, the role of CD49f in regulating the differentiation and pluripotency of stem cells …

Human dermal papilla (DP) cells have been studied extensively when grown in the
conventional monolayer. However, because of great deviation from the real in vivo three …

Multicellular spheroids can mimic the in vivo microenvironment and maintain the unique
functions of tissues, which has attracted great attention in tissue engineering. However, the …

We have succeeded in culturing human dermal papilla (DP) cell spheroids and developed a
three-dimensional (3D) Matrigel (basement membrane matrix) culture technique that can …

Abstract Three-dimensional (3D) cell culture models capable of emulating the biological
functions of natural tissues are pivotal in tissue engineering and regenerative medicine …

Background Melatonin, a neurohormone, maybe involved in physiological processes, such
as antioxidation, anti-inflammation, and hair growth. In the present study, we investigated the …

The most common form of hair loss is androgenetic alopecia (AGA). Those affected by AGA
display an increased sensitivity to androgens, which leads to reduced follicular diameter …

Loliolide is one of the most ubiquitous monoterpenoid compounds found in algae, and its
potential therapeutic effect on various dermatological conditions via agent-induced …

Unlike adult mammalian wounds, early embryonic mouse skin wounds completely
regenerate and heal without scars. Analysis of the underlying molecular mechanism will …