Cardiac muscle cells have an intrinsic ability to sense and respond to mechanical load
through a process known as mechanotransduction. In the heart, this process involves the …

Desmosomes are intercellular junctions of epithelia and cardiac muscle. They resist
mechanical stress because they adopt a strongly adhesive state in which they are said to be …

Genome-sequencing studies indicate that all humans carry many genetic variants predicted
to cause loss of function (LoF) of protein-coding genes, suggesting unexpected redundancy …

Intercellular communication is essential for proper cardiac function. Mechanical and
electrical activity need to be synchronized so that the work of individual myocytes transforms …

Intermediate filaments (IFs) play a key role in the integration of structure and function of
striated muscle, primarily by mediating mechanochemical links between the contractile …

Arrhythmogenic right ventricular dysplasia/cardiomyopathy is an inherited cardiomyopathy
estimated to affect approximately 1 in 5,000 individuals. Cardinal manifestations include …

Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a recognized cause of sudden
cardiac death, which may be prevented by timely detection and intervention. Clinical …

Arrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited disorder associated
with arrhythmias and sudden death. A recessive mutation in the gene encoding plakoglobin …

Intercalated disks (ICDs) are highly organized cell-cell adhesion structures, which connect
cardiomyocytes to one another. They are composed of three major complexes …

Cardiomyopathy is defined as a disease of functional impairment in the cardiac muscle and
its etiology includes both extrinsic and intrinsic factors. Cardiomyopathy caused by the …