DNA methylation is an epigenetic mark involved in regulating genome function and is critical
for normal development in mammals. It has been observed that the developmental …

It has become clear that early life (including in utero exposures) is a key window of
vulnerability during which environmental exposures can alter developmental trajectories …

Genetic syndromes frequently present with overlapping clinical features and inconclusive or
ambiguous genetic findings which can confound accurate diagnosis and clinical …

Birthweight is associated with health outcomes across the life course, DNA methylation may
be an underlying mechanism. In this meta-analysis of epigenome-wide association studies …

Increasing evidence points toward epigenetic variants as a risk factor for developing obesity.
We analyzed DNA methylation of the POMC (pro-opiomelanocortin) gene, which is pivotal …

Monozygotic (MZ) twins and higher-order multiples arise when a zygote splits during pre-
implantation stages of development. The mechanisms underpinning this event have …

Background DNA methylation is thought to be an important determinant of human
phenotypic variation, but its inherent cell type specificity has impeded progress on this …

The extensive exposure to per-and polyfluoroalkyl substances (PFASs) has raised public
health concerns. The issue of PFAS exposures in women with twin pregnancies remains …

Background Genetic variants can modulate phenotypic outcomes via epigenetic
intermediates, for example at methylation quantitative trait loci (mQTL). We present the first …

Background We previously associated HIST1H1E mutations causing Rahman syndrome
with a specific genome-wide methylation pattern. Results Methylome analysis from …