[HTML][HTML] The clinical use of cannabidiol and cannabidiolic acid–rich hemp in veterinary medicine and lessons from human medicine

M Ukai, S McGrath, J Wakshlag - Journal of the American …, 2023 - Am Vet Med Assoc
The endocannabinoid system (ECS) is an integral neuromodulatory system involved in
neuronal development, synaptic plasticity, and homeostasis regarding immunity, as well as …

A one health perspective on comparative cannabidiol and cannabidiolic acid pharmacokinetics and biotransformation in humans and domestic animals

WS Schwark, JJ Wakshlag - American Journal of Veterinary …, 2023 - Am Vet Med Assoc
The goal of pharmacokinetic (PK) studies is to provide a basis for appropriate dosing
regimens with novel therapeutic agents. With a knowledge of the desired serum …

Endocannabinoid system and phytocannabinoids in the main species of veterinary interest: a comparative review

A Di Salvo, E Chiaradia, M Sforna… - Veterinary Research …, 2024 - Springer
Since the discovery of the endocannabinoid system and due to the empirical evidence of the
therapeutic effects on several illnesses both in humans and animals that follow the …

Tolerability of 2 and 4 mg/kg dosing every 12 hour of a Cannabidiol-and Cannabidiolic acid-rich hemp extract on mixed-breed dogs utilized for teaching in a closed …

T Mills, S Myers, D Hughes, J Wakshlag - Animals, 2024 - mdpi.com
Simple Summary Considering the increasing popularity of cannabinoid-rich hemp-based full-
spectrum nutraceuticals, there is a need to better understand the tolerability and adverse …

Pharmacokinetics of cannabidiol-/cannabidiolic acid-rich hemp oil in juvenile cynomolgus macaques (Macaca fascicularis)

TN Johns, JJ Wakshlag, AV Lyubimov… - Frontiers in Veterinary …, 2023 - frontiersin.org
Introduction Cannabinoids are increasingly popular in human and veterinary medicine and
have been studied as an alternative treatment for a wide range of disorders. The goal of this …

Pharmacokinetics behavior of four cannabidiol preparations following single oral administration in dogs

S Limsuwan, N Phonsatta, A Panya… - Frontiers in Veterinary …, 2024 - frontiersin.org
Cannabidiol (CBD) is a natural phytochemical agent and one of the most abundant found in
Cannabis sativa. It is known to exhibit pharmacological properties on various condition such …

Chronic oral dosing of cannabidiol and cannabidiolic acid full-spectrum hemp oil extracts has no adverse effects in horses: a pharmacokinetic and safety study

TC Wang, JJ Wakshlag, MC Jager… - American Journal of …, 2025 - Am Vet Med Assoc
OBJECTIVE To compare the pharmacokinetics of cannabidiol (CBD) and cannabidiolic acid
(CBDA) in horses and to evaluate the safety of their chronic administration. METHODS CBD …

Twice-daily oral administration of a cannabidiol and cannabidiolic acid–rich hemp extract was well tolerated in orange-winged Amazon parrots (Amazona amazonica) …

M Sosa-Higareda, DSM Guzman… - American Journal of …, 2023 - Am Vet Med Assoc
OBJECTIVE To determine the pharmacokinetics of 8 cannabinoids and 5 metabolites after
oral administration of single and multiple doses of a cannabidiol (CBD)-cannabidiolic acid …

Cannabidiol can affect morphology, morphometry, enzymatic and microbial activity of rabbit digestive system

N Musco, G Pascon, NF Addeo… - Journal of Animal …, 2024 - academic.oup.com
The present research aimed to evaluate the effects of the continuative dietary administration
of a hemp oil extract containing cannabinoids (cannabidiol, CBD) on the macroscopic …

Determination of cannabinoids in plasma

N Borg - 2024 - um.edu.mt
The use of cannabis in the medical industry is increasing. Tetrahydrocannabinol (THC)'s
psychoactive properties and Cannabidiol (CBD)'s analgesic, neuroprotective …