[HTML][HTML] Viral innate immune evasion and the pathogenesis of emerging RNA virus infections

T Nelemans, M Kikkert - Viruses, 2019 - mdpi.com
Positive-sense single-stranded RNA (+ ssRNA) viruses comprise many (re-) emerging
human pathogens that pose a public health problem. Our innate immune system and, in …

[HTML][HTML] Recent progress in vaccine development against chikungunya virus

S Gao, S Song, L Zhang - Frontiers in microbiology, 2019 - frontiersin.org
Chikungunya fever (CHIKF) is an acute infectious disease that is mediated by the mosquito-
transmitted chikungunya virus (CHIKV). People infected with CHIKV may experience high …

Encephalitis and poor neuronal death–mediated control of herpes simplex virus in human inherited RIPK3 deficiency

Z Liu, EJ Garcia Reino, O Harschnitz, H Guo… - Science …, 2023 - science.org
Inborn errors of TLR3-dependent type I IFN immunity in cortical neurons underlie forebrain
herpes simplex virus-1 (HSV-1) encephalitis (HSE) due to uncontrolled viral growth and …

[HTML][HTML] Current status of chikungunya in India

… Consortia (TRC) for Chikungunya Virus in … - Frontiers in …, 2021 - frontiersin.org
Chikungunya fever (CHIKF) is an arbovirus disease caused by chikungunya virus (CHIKV),
an alphavirus of Togaviridae family. Transmission follows a human-mosquito-human cycle …

Mechanistic insights into bone remodelling dysregulation by human viral pathogens

CCS Caetano, T Azamor, NM Meyer… - Nature …, 2024 - nature.com
Bone-related diseases (osteopathologies) associated with human virus infections have
increased around the globe. Recent findings have highlighted the intricate interplay …

Sensitivity of alphaviruses to G3BP deletion correlates with efficiency of replicase polyprotein processing

B Götte, A Utt, R Fragkoudis, A Merits… - Journal of …, 2020 - Am Soc Microbiol
We present a comprehensive overview of the dependency of several Old World
alphaviruses for the host protein G3BP. Based on their replication ability in G3BP-deleted …

Evolution and immunopathology of chikungunya virus informs therapeutic development

F Henderson Sousa… - Disease Models & …, 2023 - journals.biologists.com
Chikungunya virus (CHIKV), a mosquito-borne alphavirus, is an emerging global threat
identified in more than 60 countries across continents. The risk of CHIKV transmission is …

[HTML][HTML] An overview of anti-chikungunya antibody response in natural infection and vaccine-mediated immunity, including anti-CHIKV vaccine candidates and …

P Chandley, A Lukose, R Kumar, S Rohatgi - The Microbe, 2023 - Elsevier
Chikungunya virus (CHIKV) is an arthropod-borne alphavirus which infects people severely
and is responsible for epidemic outbreaks worldwide. Despite its rising prevalence globally …

Live-attenuated chikungunya virus vaccine

LFP Ng, L Rénia - Cell, 2024 - cell.com
Although Chikungunya fever does not a have a high fatality rate (< 10%), it has a huge
morbidity toll due to lingering chronic arthralgia. The recent FDA approval of Ixchiq, a …

[HTML][HTML] Liposomal delivery of the RNA genome of a live-attenuated chikungunya virus vaccine candidate provides local, but not systemic protection after one dose

E Abeyratne, K Tharmarajah, JR Freitas… - Frontiers in …, 2020 - frontiersin.org
Chikungunya virus (CHIKV) is the causative pathogen of chikungunya fever, a mosquito-
borne viral disease causing highly debilitating arthralgia that can persist for months and …