Mitophagy is an evolutionarily conserved process involving the autophagic targeting and
clearance of mitochondria destined for removal. Recent insights into the complex nature of …

As reperfusion therapies have become more widely used in acute myocardial infarction
patients, ischemia-induced myocardial damage has been markedly reduced, but reperfusion …

The oocyte is recognised as the largest cell in mammalian species and other multicellular
organisms. Mitochondria represent a high proportion of the cytoplasm in oocytes and …

Metastasis is the major cause of cancer deaths, and cancer cells evolve to adapt to various
tumor microenvironments, which hinders the treatment of tumor metastasis. Platelets play …

In vitro studies have established the prevalent theory that the mitochondrial kinase PINK1
protects neurodegeneration by removing damaged mitochondria in Parkinson's disease …

Parkinson's disease (PD) is the second-most-common neurodegenerative disease
characterized by motor and non-motor dysfunctions, which currently affects about 10 million …

PINK1 loss-of-function mutations cause early onset Parkinson disease. PINK1-Parkin
mediated mitophagy has been well studied, but the relevance of the endogenous process in …

The selective removal of damaged mitochondria, also known as mitophagy, is an important
mechanism that regulates mitochondrial quality control. Evidence suggests that mitophagy is …

Heart failure is the leading cause of mortality in patients with end-stage renal disease, and
progressive cardiac remodeling is the key pathological basis of heart failure. However, the …

Burn injuries are a significant cause of death worldwide, leading to systemic inflammation,
multiple organ failure and sepsis. The progression of burn injury is explicitly correlated with …