[HTML][HTML] TGF-β as a key modulator of astrocyte reactivity: disease relevance and therapeutic implications

J Luo - Biomedicines, 2022 - mdpi.com
Astrocytes are essential for normal brain development and functioning. They respond to
brain injury and disease through a process referred to as reactive astrogliosis, where the …

[HTML][HTML] Photobiomodulation for the treatment of neuroinflammation: A systematic review of controlled laboratory animal studies

FS Cardoso, F Salehpour, NC Coimbra… - Frontiers in …, 2022 - frontiersin.org
Background Neuroinflammation is a response that involves different cell lineages of the
central nervous system, such as neurons and glial cells. Among the non-pharmacological …

[HTML][HTML] Photobiomodulation inhibits the activation of neurotoxic microglia and astrocytes by inhibiting Lcn2/JAK2-STAT3 crosstalk after spinal cord injury in male rats

X Wang, X Li, X Zuo, Z Liang, T Ding, K Li, Y Ma… - Journal of …, 2021 - Springer
Background Neurotoxic microglia and astrocytes begin to activate and participate in
pathological processes after spinal cord injury (SCI), subsequently causing severe …

[HTML][HTML] Promoted CD4+ T cell-derived IFN-γ/IL-10 by photobiomodulation therapy modulates neurogenesis to ameliorate cognitive deficits in APP/PS1 and 3xTg-AD …

X Wu, Q Shen, H Chang, J Li, D Xing - Journal of Neuroinflammation, 2022 - Springer
Background The immune system has been implicated in synaptic plasticity, inflammation,
and the progression of Alzheimer's disease (AD). However, there were few studies on …

[HTML][HTML] Lysine 63-linked ubiquitination of tau oligomers contributes to the pathogenesis of Alzheimer's disease

N Puangmalai, U Sengupta, N Bhatt, S Gaikwad… - Journal of Biological …, 2022 - ASBMB
Ubiquitin-modified tau aggregates are abundantly found in human brains diagnosed with
Alzheimer's disease (AD) and other tauopathies. Soluble tau oligomers (TauO) are the most …

[HTML][HTML] Astroglial Cells: Emerging Therapeutic Targets in the Management of Traumatic Brain Injury

W Czyżewski, M Mazurek, L Sakwa, M Szymoniuk… - Cells, 2024 - mdpi.com
Traumatic Brain Injury (TBI) represents a significant health concern, necessitating advanced
therapeutic interventions. This detailed review explores the critical roles of astrocytes, key …

UCHL1 impairs periodontal ligament stem cell osteogenesis in periodontitis

L Lin, S Li, S Hu, W Yu, B Jiang, C Mao… - Journal of Dental …, 2023 - journals.sagepub.com
Periodontitis comprises a series of inflammatory responses resulting in alveolar bone loss.
The suppression of osteogenesis of periodontal ligament stem cells (PDLSCs) by …

[HTML][HTML] Microglia-Mediated Inflammation and Neural Stem Cell Differentiation in Alzheimer's Disease: Possible Therapeutic Role of KV1.3 Channel Blockade

M Revuelta, J Urrutia, A Villarroel… - Frontiers in Cellular …, 2022 - frontiersin.org
Increase of deposits of amyloid β peptides in the extracellular matrix is landmark during
Alzheimer's Disease (AD) due to the imbalance in the production vs. clearance. This …

A systematic review of the effect of photobiomodulation on the neuroinflammatory response in animal models of neurodegenerative diseases

K Xie, H El Khoury, J Mitrofanis… - Reviews in the …, 2023 - degruyter.com
This systematic review examines the effect of photobiomodulation (PBM), the application of
red to near infrared light on body tissues, on the neuroinflammatory response and oxidative …

[HTML][HTML] MiR-431 attenuates synaptic plasticity and memory deficits in APPswe/PS1dE9 mice

J Ge, Z Xue, S Shu, L Yu, R Qin, W Tao, P Liu, X Dong… - JCI insight, 2023 - ncbi.nlm.nih.gov
Synaptic plasticity impairment plays a critical role in the pathogenesis of Alzheimer's disease
(AD), and emerging evidence has shown that microRNAs (miRs) are alternative biomarkers …