Generation of circadian rhythms in the suprachiasmatic nucleus
MH Hastings, ES Maywood… - Nature Reviews …, 2018 - nature.com
The suprachiasmatic nucleus (SCN) of the hypothalamus is remarkable. Despite numbering
only about 10,000 neurons on each side of the third ventricle, the SCN is our principal …
only about 10,000 neurons on each side of the third ventricle, the SCN is our principal …
Circadian rhythms and astrocytes: the good, the bad, and the ugly
MH Hastings, M Brancaccio… - Annual review of …, 2023 - annualreviews.org
This review explores the interface between circadian timekeeping and the regulation of
brain function by astrocytes. Although astrocytes regulate neuronal activity across many time …
brain function by astrocytes. Although astrocytes regulate neuronal activity across many time …
Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity
Genome-wide association studies (GWAS) have identified> 250 loci for body mass index
(BMI), implicating pathways related to neuronal biology. Most GWAS loci represent clusters …
(BMI), implicating pathways related to neuronal biology. Most GWAS loci represent clusters …
Single nuclei RNA-seq of mouse placental labyrinth development
B Marsh, R Blelloch - Elife, 2020 - elifesciences.org
The placenta is the interface between mother and fetus in all eutherian species. However,
our understanding of this essential organ remains incomplete. A substantial challenge has …
our understanding of this essential organ remains incomplete. A substantial challenge has …
Rhythmic cilia changes support SCN neuron coherence in circadian clock
HQ Tu, S Li, YL Xu, YC Zhang, PY Li, LY Liang… - Science, 2023 - science.org
The suprachiasmatic nucleus (SCN) drives circadian clock coherence through intercellular
coupling, which is resistant to environmental perturbations. We report that primary cilia are …
coupling, which is resistant to environmental perturbations. We report that primary cilia are …
Regulating the suprachiasmatic nucleus (SCN) circadian clockwork: interplay between cell-autonomous and circuit-level mechanisms
ED Herzog, T Hermanstyne… - Cold Spring …, 2017 - cshperspectives.cshlp.org
The suprachiasmatic nucleus (SCN) is the principal circadian clock of the brain, directing
daily cycles of behavior and physiology. SCN neurons contain a cell-autonomous …
daily cycles of behavior and physiology. SCN neurons contain a cell-autonomous …
A shared transcriptional code orchestrates temporal patterning of the central nervous system
The molecular mechanisms that produce the full array of neuronal subtypes in the vertebrate
nervous system are incompletely understood. Here, we provide evidence of a global …
nervous system are incompletely understood. Here, we provide evidence of a global …
Regulatory variants at KLF14 influence type 2 diabetes risk via a female-specific effect on adipocyte size and body composition
Individual risk of type 2 diabetes (T2D) is modified by perturbations to the mass, distribution
and function of adipose tissue. To investigate the mechanisms underlying these …
and function of adipose tissue. To investigate the mechanisms underlying these …
Off the clock: from circadian disruption to metabolic disease
E Maury - International journal of molecular sciences, 2019 - mdpi.com
Circadian timekeeping allows appropriate temporal regulation of an organism's internal
metabolism to anticipate and respond to recurrent daily changes in the environment …
metabolism to anticipate and respond to recurrent daily changes in the environment …
[HTML][HTML] Assessing mouse behaviour throughout the light/dark cycle using automated in-cage analysis tools
An important factor in reducing variability in mouse test outcomes has been to develop
assays that can be used for continuous automated home cage assessment. Our experience …
assays that can be used for continuous automated home cage assessment. Our experience …