[HTML][HTML] Beyond t test and ANOVA: applications of mixed-effects models for more rigorous statistical analysis in neuroscience research
In basic neuroscience research, data are often clustered or collected with repeated
measures, hence correlated. The most widely used methods such as t test and ANOVA do …
measures, hence correlated. The most widely used methods such as t test and ANOVA do …
Psychedelics promote plasticity by directly binding to BDNF receptor TrkB
R Moliner, M Girych, CA Brunello, V Kovaleva… - Nature …, 2023 - nature.com
Psychedelics produce fast and persistent antidepressant effects and induce neuroplasticity
resembling the effects of clinically approved antidepressants. We recently reported that …
resembling the effects of clinically approved antidepressants. We recently reported that …
Ketamine: neuroprotective or neurotoxic?
Ketamine, a non-competitive N-methyl-D-aspartate receptor (NMDAR) antagonist, has been
employed clinically as an intravenous anesthetic since the 1970s. More recently, ketamine …
employed clinically as an intravenous anesthetic since the 1970s. More recently, ketamine …
Psychedelics reopen the social reward learning critical period
R Nardou, E Sawyer, YJ Song, M Wilkinson… - Nature, 2023 - nature.com
Psychedelics are a broad class of drugs defined by their ability to induce an altered state of
consciousness,. These drugs have been used for millennia in both spiritual and medicinal …
consciousness,. These drugs have been used for millennia in both spiritual and medicinal …
Psychedelics and neural plasticity: therapeutic implications
Psychedelic drugs have reemerged as tools to treat several brain disorders. Cultural
attitudes toward them are changing, and scientists are once again investigating the neural …
attitudes toward them are changing, and scientists are once again investigating the neural …
Single-cell epigenome analysis reveals age-associated decay of heterochromatin domains in excitatory neurons in the mouse brain
Loss of heterochromatin has been implicated as a cause of pre-mature aging and age-
associated decline in organ functions in mammals; however, the specific cell types and gene …
associated decline in organ functions in mammals; however, the specific cell types and gene …
Microglia elimination increases neural circuit connectivity and activity in adult mouse cortex
YJ Liu, EE Spangenberg, B Tang… - Journal of …, 2021 - Soc Neuroscience
Microglia have crucial roles in sculpting synapses and maintaining neural circuits during
development. To test the hypothesis that microglia continue to regulate neural circuit …
development. To test the hypothesis that microglia continue to regulate neural circuit …
Critical period plasticity as a framework for psychedelic-assisted psychotherapy
As psychedelic compounds gain traction in psychiatry, there is a need to consider the active
mechanism to explain the effect observed in randomized clinical trials. Traditionally …
mechanism to explain the effect observed in randomized clinical trials. Traditionally …
Ketamine ameliorates post-traumatic social avoidance by erasing the traumatic memory encoded in VTA-innervated BLA engram cells
M Li, XK Yang, J Yang, TX Li, C Cui, X Peng, J Lei… - Neuron, 2024 - cell.com
Erasing traumatic memory during memory reconsolidation is a promising retrieval-extinction
strategy for post-traumatic stress disorder (PTSD). Here, we developed an acute social …
strategy for post-traumatic stress disorder (PTSD). Here, we developed an acute social …
Erythrocyte–brain endothelial interactions induce microglial responses and cerebral microhemorrhages in vivo
Background Cerebral microhemorrhages (CMH) are associated with stroke, cognitive
decline, and normal aging. Our previous study shows that the interaction between …
decline, and normal aging. Our previous study shows that the interaction between …