A mini review on synthetic approaches and biological activities of benzodiazepines
Background: Benzodiazepines (BDZs) are the bicyclic heterocyclic compounds in which
benzene ring is fused to seven membered ring containing two nitrogen atoms. There are …
benzene ring is fused to seven membered ring containing two nitrogen atoms. There are …
Sugar-Based Enantiomeric and Conformationally Constrained Pyrrolo[2,1-c][1,4]-Benzodiazepines as Potential GABAA Ligands
Synthesis of a library of pyrrolo [2, 1-c][1, 4]-benzodiazepines derived from spiro bicyclic d-or
l-proline analogues containing a d-or l-fructose moiety was developed. The l-fructose moiety …
l-proline analogues containing a d-or l-fructose moiety was developed. The l-fructose moiety …
Chiromers: conformation-driven mirror-image supramolecular chirality isomerism identified in a new class of helical rosette nanotubes
Rosette nanotubes are biologically inspired nanostructures, formed through the hierarchical
organization of a hybrid DNA base analogue (G∧ C), which features hydrogen-bonding …
organization of a hybrid DNA base analogue (G∧ C), which features hydrogen-bonding …
Synthesis and Biological Evaluation of Novel Rigid 1, 4‐Benzodiazepine‐2, 5‐dione Chimeric Scaffolds
Abstract Novel, conformationally constrained 1, 4‐benzodiazepine‐2, 5‐diones containing
both a monosaccharide, fructose, and a proline moiety have been synthesized as chimeric …
both a monosaccharide, fructose, and a proline moiety have been synthesized as chimeric …
Evaluation of a chiral stationary phase derived from a simple Diels‐Alder reaction
L Thunberg, S Allenmark - Chirality: The Pharmacological …, 2003 - Wiley Online Library
The bicyclic, C2‐symmetric dicarboxylic acid obtained from the cycloaddition of fumaric acid
to anthracene can readily be prepared in enantiomerically pure form on a large scale …
to anthracene can readily be prepared in enantiomerically pure form on a large scale …
Probing HSA and AGP drug-binding sites by electronic circular dichroism
M Simonyi - Comprehensive Chiroptical Spectroscopy, 2012 - Wiley Online Library
Probing HSA and AGP drug-binding sites by electronic circular dichroism Page 676 21
PROBING HSA AND AGP DRUG-BINDING SITES BY ELECTRONIC CIRCULAR DICHROISM …
PROBING HSA AND AGP DRUG-BINDING SITES BY ELECTRONIC CIRCULAR DICHROISM …
Enantiomerization of 3‐Carbethoxy‐l, 4‐benzodiazepin‐2‐one: Combined chiral HPLC and spectroscopic study
A Abatangelo, F Zanetti, L Navarini, D Kontrec… - Chirality, 2002 - Wiley Online Library
Recently developed chiral HPLC columns CHIRIS AD1 and CHIRIS AD2 have been
demonstrated to separate racemic, configurationally unstable ethyl‐7‐chloro‐2‐oxo‐5 …
demonstrated to separate racemic, configurationally unstable ethyl‐7‐chloro‐2‐oxo‐5 …
syn/anti Diastereoselectivity in the Aldol Reaction of Aldehydes with the C(3) Carbanion of 1,3‐Dihydro‐2H‐1,4‐benzodiazepin‐2‐one
D Marković, Z Hameršak, A Višnjevac… - Helvetica chimica …, 2000 - Wiley Online Library
The aldol reaction of the C (3) carbanion of 7‐chloro‐1, 3‐dihydro‐1‐methyl‐5‐phenyl‐2H‐
1, 4‐benzodiazepin‐2‐one (2) with a series of aromatic and aliphatic aldehydes at− 78° …
1, 4‐benzodiazepin‐2‐one (2) with a series of aromatic and aliphatic aldehydes at− 78° …
Diastereoselective aldol reaction of 7-bromo-5-pyrido-1, 4-benzodiazepin-2-one; Relative and absolute configuration of all stereoisomers
M Majerić-Elenkov, D Žiher, A Višnjevac… - Croatica chemica …, 2001 - hrcak.srce.hr
Sažetak Aldol reaction of C (3) carbanion of 7-bromo-5-pyrido-1, 4-benzodia-zepin-2-one
(1) with representative aliphatic and aromatic aldehydes and ketones afforded racemic …
(1) with representative aliphatic and aromatic aldehydes and ketones afforded racemic …
On the Way to α-Methyl-α-amino Acids; Unusual Elimination-addition in 3, 3-Disubstituted 1, 4-Benzodiazepin-2-ones and Inversion of Enantioselectivity in the Lipase …
A Avdagić, V Šunjić - Croatica chemica acta, 2000 - hrcak.srce.hr
Sažetak (−)-3-Methanesulfoxymethyl-3-acetoxoymethyl-7-chloro-5-phenyl-1, 4-
benzodiazepin-2-one,(−)-2, reacts with ethanethiol in the presence of a strong base …
benzodiazepin-2-one,(−)-2, reacts with ethanethiol in the presence of a strong base …