Tissue clearing and its applications in neuroscience
State-of-the-art tissue-clearing methods provide subcellular-level optical access to intact
tissues from individual organs and even to some entire mammals. When combined with light …
tissues from individual organs and even to some entire mammals. When combined with light …
Tissue clearing
Tissue clearing of gross anatomical samples was first described more than a century ago
and has only recently found widespread use in the field of microscopy. This renaissance has …
and has only recently found widespread use in the field of microscopy. This renaissance has …
Capturing cardiogenesis in gastruloids
Organoids are powerful models for studying tissue development, physiology, and disease.
However, current culture systems disrupt the inductive tissue-tissue interactions needed for …
However, current culture systems disrupt the inductive tissue-tissue interactions needed for …
Integration of optogenetics with complementary methodologies in systems neuroscience
Modern optogenetics can be tuned to evoke activity that corresponds to naturally occurring
local or global activity in timing, magnitude or individual-cell patterning. This outcome has …
local or global activity in timing, magnitude or individual-cell patterning. This outcome has …
Magnetically actuated microrobots as a platform for stem cell transplantation
S Jeon, S Kim, S Ha, S Lee, E Kim, SY Kim, SH Park… - Science Robotics, 2019 - science.org
Magnetic microrobots were developed for three-dimensional culture and the precise delivery
of stem cells in vitro, ex vivo, and in vivo. Hippocampal neural stem cells attached to the …
of stem cells in vitro, ex vivo, and in vivo. Hippocampal neural stem cells attached to the …
A fully automated high-throughput workflow for 3D-based chemical screening in human midbrain organoids
H Renner, M Grabos, KJ Becker, TE Kagermeier, J Wu… - elife, 2020 - elifesciences.org
Three-dimensional (3D) culture systems have fueled hopes to bring about the next
generation of more physiologically relevant high-throughput screens (HTS). However …
generation of more physiologically relevant high-throughput screens (HTS). However …
Neuroprosthetic baroreflex controls haemodynamics after spinal cord injury
Spinal cord injury (SCI) induces haemodynamic instability that threatens survival,–, impairs
neurological recovery,, increases the risk of cardiovascular disease,, and reduces quality of …
neurological recovery,, increases the risk of cardiovascular disease,, and reduces quality of …
Whole-brain profiling of cells and circuits in mammals by tissue clearing and light-sheet microscopy
Tissue clearing and light-sheet microscopy have a 100-year-plus history, yet these fields
have been combined only recently to facilitate novel experiments and measurements in …
have been combined only recently to facilitate novel experiments and measurements in …
Advancing models of neural development with biomaterials
Human pluripotent stem cells have emerged as a promising in vitro model system for
studying the brain. Two-dimensional and three-dimensional cell culture paradigms have …
studying the brain. Two-dimensional and three-dimensional cell culture paradigms have …
Versatile whole-organ/body staining and imaging based on electrolyte-gel properties of biological tissues
Whole-organ/body three-dimensional (3D) staining and imaging have been enduring
challenges in histology. By dissecting the complex physicochemical environment of the …
challenges in histology. By dissecting the complex physicochemical environment of the …