Carotenoids are natural lipid-soluble antioxidants abundantly found as colorful pigments in
fruits and vegetables. At least 600 carotenoids occur naturally, although about 20 of them …

Diabetes mellitus is a heterogeneous chronic metabolic disorder characterized by the
presence of hyperglycemia, commonly preceded by a prediabetic state. The excess of blood …

Retinal pigment epithelium (RPE) degeneration plays an important role in a group of retinal
disorders such as retinal degeneration (RD) and age-related macular degeneration (AMD) …

Lutein is a xanthophyll carotenoid obtained from various foods, such as dark green leafy
vegetables and egg yolk. Lutein has antioxidant activity and scavenges reactive oxygen …

Diabetic retinopathy (DR), one of the common complications of diabetes, is the leading
cause of visual loss in working-age individuals in many industrialized countries. It has been …

Acute inflammation is a key component of the immune system's response to pathogens, toxic
agents, or tissue injury, involving the stimulation of defense mechanisms aimed to removing …

Apoptosis, programmed cell death type I, is a critical part of neurodegeneration in cerebral
ischemia, Parkinson's, and Alzheimer's disease. Apoptosis begins with activation of pro …

Rationale Oxidative stress plays a critical role in the development of cardiac remodeling and
heart failure. Lutein, the predominant nonvitamin A carotenoid, has been shown to have …

Diabetic retinopathy has recently been defined as a highly specific neurovascular
complication of diabetes. The chronic progression of the impairment of the interdependence …

The investigation aimed to evaluate the effects of Mcc950, an inhibitor of the NLRP3
inflammasome, on diabetic retinopathy (DR) mice. The general physiological condition of …