Although enhancers are crucial and widespread gene-regulatory elements, we are far from
a complete understanding of how they function or their importance in areas such as disease …

Diabetes mellitus is a lifelong, metabolic disease that is characterised by an inability to
maintain normal glucose homeostasis. There are several different forms of diabetes …

The development of chemotherapy resistance is the most vital obstacle to clinical efficacy in
gastric cancer (GC). The dysregulation of the Wnt/beta-catenin signaling pathway is critically …

Abstract Type 2 diabetes (T2D) is the result of interaction between environmental factors and
a strong hereditary component. We review the heritability of T2D as well as the history of …

Type 2 diabetes (T2D) is characterized by insulin resistance and increased hepatic glucose
production, yet the molecular mechanisms underlying these abnormalities are poorly …

Sclerostin has traditionally been thought of as a local inhibitor of bone acquisition that
antagonizes the profound osteoanabolic capacity of activated Wnt/β-catenin signaling, but …

Plasmodium falciparum (Pf) parasite development in liver represents the initial step of the
life-cycle in the human host after a Pf-infected mosquito bite. While an attractive stage for life …

Understanding the regulation of islet cell mass has important implications for the discovery
of regenerative therapies for diabetes. The liver plays a central role in metabolism and the …

Hair follicle stem cells (HFSCs) regenerate hair in response to Wnt signalling. Here, we
unfold genome-wide transcriptional and chromatin landscapes of β-catenin–TCF3/4–TLE …

In mammals, Wnt/β-catenin signaling features prominently in stem cells and cancers, but
how and for what purposes have been matters of much debate. In this review, we summarize …