Skin barrier dysfunction, a defining feature of atopic dermatitis (AD), arises from multiple
interacting systems. In AD, skin inflammation is caused by host–environment interactions …

Rapid advances in soft electronics, microfabrication technologies, miniaturization and
electronic skins are facilitating the development of wearable sensor devices that are highly …

Although, drugs are required in the various skin compartments such as viable epidermis,
dermis, or hair follicles, to efficiently treat skin diseases, drug delivery into and across the …

The skin protects our body from external assaults like pathogens, xenobiotics or UV
irradiation. In addition, it prevents the loss of water and solutes. To fulfill these important …

Generation of a barrier in multi-layered epithelia like the epidermis requires restricted
positioning of functional tight junctions (TJ) to the most suprabasal viable layer. This …

The desmosomal cadherin desmoglein-1 (DSG1) is an essential intercellular adhesion
molecule that is altered in various human cutaneous disorders; however, its regulation and …

The skin, the largest organ of the body, is an essential barrier that under homeostatic
conditions efficiently protects and/or minimizes damage from both environmental (eg …

The transmembrane protein claudin-1 is a major component of epidermal tight junctions
(TJs), which create a dynamic paracellular barrier in the epidermis. Claudin-1 …

The topical application of drug-loaded particles has been explored extensively aiming at a
dermal, follicular or transdermal drug delivery. This review summarizes the present state of …

Tight junctions are important for skin barrier function. The tight junction protein claudin 1
(Cldn-1) has been reported to be down-regulated in nonlesional skin of atopic dermatitis …