Therapeutic peptides: current applications and future directions

L Wang, N Wang, W Zhang, X Cheng, Z Yan… - Signal transduction and …, 2022 - nature.com
Peptide drug development has made great progress in the last decade thanks to new
production, modification, and analytic technologies. Peptides have been produced and …

[HTML][HTML] Systematic review and meta-analysis of the effectiveness and perinatal outcomes of COVID-19 vaccination in pregnancy

S Prasad, E Kalafat, H Blakeway, R Townsend… - Nature …, 2022 - nature.com
Safety and effectiveness of COVID-19 vaccines during pregnancy is a particular concern
affecting vaccination uptake by this vulnerable group. Here we evaluated evidence from 23 …

Trajectory of long covid symptoms after covid-19 vaccination: community based cohort study

D Ayoubkhani, C Bermingham, KB Pouwels… - bmj, 2022 - bmj.com
Objective To estimate associations between covid-19 vaccination and long covid symptoms
in adults with SARS-CoV-2 infection before vaccination. Design Observational cohort study …

[HTML][HTML] Safety, tolerability and viral kinetics during SARS-CoV-2 human challenge in young adults

B Killingley, AJ Mann, M Kalinova, A Boyers… - Nature Medicine, 2022 - nature.com
Since its emergence in 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-
2) has caused hundreds of millions of cases and continues to circulate globally. To establish …

The Omicron variant is highly resistant against antibody-mediated neutralization: Implications for control of the COVID-19 pandemic

M Hoffmann, N Krüger, S Schulz, A Cossmann… - Cell, 2022 - cell.com
The rapid spread of the SARS-CoV-2 Omicron variant suggests that the virus might become
globally dominant. Further, the high number of mutations in the viral spike protein raised …

Emerging COVID-19 variants and their impact on SARS-CoV-2 diagnosis, therapeutics and vaccines

Q Fernandes, VP Inchakalody, M Merhi… - Annals of …, 2022 - Taylor & Francis
The emergence of novel and evolving variants of SARS-CoV-2 has fostered the need for
change in the form of newer and more adaptive diagnostic methods for the detection of …

[HTML][HTML] Immune imprinting, breadth of variant recognition, and germinal center response in human SARS-CoV-2 infection and vaccination

K Röltgen, SCA Nielsen, O Silva, SF Younes… - Cell, 2022 - cell.com
During the SARS-CoV-2 pandemic, novel and traditional vaccine strategies have been
deployed globally. We investigated whether antibodies stimulated by mRNA vaccination …

[HTML][HTML] Real-world effectiveness of COVID-19 vaccines: a literature review and meta-analysis

C Zheng, W Shao, X Chen, B Zhang, G Wang… - International journal of …, 2022 - Elsevier
Objective To estimate the coronavirus disease 2019 (COVID-19) vaccine effectiveness (VE)
against concerned outcomes in real-world settings. Methods Studies reporting COVID-19 VE …

Effect of Covid-19 vaccination on transmission of alpha and delta variants

DW Eyre, D Taylor, M Purver, D Chapman… - … England Journal of …, 2022 - Mass Medical Soc
Background Before the emergence of the B. 1.617. 2 (delta) variant of severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), vaccination reduced transmission of …

The biological and clinical significance of emerging SARS-CoV-2 variants

K Tao, PL Tzou, J Nouhin, RK Gupta… - Nature Reviews …, 2021 - nature.com
The past several months have witnessed the emergence of SARS-CoV-2 variants with novel
spike protein mutations that are influencing the epidemiological and clinical aspects of the …