Cutaneous T cell lymphomas (CTCLs) are a heterogeneous group of extranodal non-
Hodgkin's lymphomas that are characterized by a cutaneous infiltration of malignant …

Transcription factors (TFs) act as major oncodrivers in many cancers and are frequently
regarded as high-value therapeutic targets. The functionality of TFs relies on direct protein …

Cutaneous T-cell lymphoma (CTCL) is characterized by proliferation of malignant T cells in a
chronic inflammatory environment. With disease progression, bacteria colonize the …

Aberrant activation of Janus kinase-3 (Jak3) and its key down-stream effectors, Signal
Transducer and Activator of Transcription-3 (STAT3) and STAT5, is a key feature of …

ABSTRACT Cutaneous T-Cell Lymphomas (CTCL) are rare, but potentially devastating
malignancies, whose pathogenesis remains poorly elucidated. Unfortunately, currently it is …

Immunostaining of non-adherent cells is commonly performed after adhesion of cells onto
microscope slides either using cytocentrifugation or with the help of charged coating …

A plethora of mutations in chromatin regulators in diverse human cancers is emerging,
attesting to the pivotal role of chromatin dynamics in tumorigenesis. A recurrent theme is …

HTLV-1 is estimated to affect~ 20 million people worldwide and in~ 5% of carriers it
produces Adult T-Cell Leukemia/Lymphoma (ATLL), which can often masquerade and …

Cutaneous T-Cell Lymphomas (CTCL) presents with substantial clinical variability and
transcriptional heterogeneity. In the recent years, several studies paved the way to elucidate …

Histone eviction and chromatin relaxation are important processes for efficient DNA repair.
Poly (ADP) ribose (PAR) polymerase 1 (PARP1) is a key mediator of this process, and …