Major depressive disorder is a highly debilitating psychiatric disorder involving the
dysfunction of different cell types in the brain. Microglia are the predominant resident …

Adult neurogenesis occurs mainly in the subgranular zone of the hippocampal dentate gyrus
and the subventricular zone of the lateral ventricles. Evidence supports the critical role of …

Enhancing neurogenesis within the hippocampal dentate gyrus (DG) is critical for
maintaining brain development and function in many neurological diseases. However, the …

Epidemiological studies indicate that the consumption of caffeine, the most commonly
ingested psychoactive substance found in coffee, tea or soft drinks, reduces the risk of …

Chronic stress is a major risk factor for various psychiatric diseases, including depression; it
triggers various cellular and structural changes, resulting in the alteration of neurocircuitry …

Cocoa is widely known for its health benefits, but its neurocognitive impact remains
underexplored. This preclinical study aimed to investigate the effects of cocoa and cocoa …

High-risk preterm infants are affected by a higher incidence of cognitive developmental
deficits due to the unavoidable risk factor of oxygen toxicity. Caffeine is known to have a …

Depressive conditions precipitated by repeated stress are a major socio-economical burden
in Western countries. Previous studies showed that ATP-P2X7 receptors (P2X7R) and …

The activation of microglia is an important cause of central nervous system (CNS)
inflammatory cell infiltration and inflammatory demyelination in experimental autoimmune …

Daily intake of tea has been known to relate to a low risk of depression. In this study, we
report that a special variety of tea in China, Camellia assamica var. kucha (kucha) …