Rare and common variants: twenty arguments
G Gibson - Nature Reviews Genetics, 2012 - nature.com
Genome-wide association studies have greatly improved our understanding of the genetic
basis of disease risk. The fact that they tend not to identify more than a fraction of the specific …
basis of disease risk. The fact that they tend not to identify more than a fraction of the specific …
A microRNA linking human positive selection and metabolic disorders
Positive selection in Europeans at the 2q21. 3 locus harboring the lactase gene has been
attributed to selection for the ability of adults to digest milk to survive famine in ancient times …
attributed to selection for the ability of adults to digest milk to survive famine in ancient times …
Complexity of microRNA function and the role of isomiRs in lipid homeostasis
KC Vickers, P Sethupathy, J Baran-Gale… - Journal of lipid …, 2013 - ASBMB
MicroRNAs (miRNAs) are key posttranscriptional regulators of biological pathways that
govern lipid metabolic phenotypes. Recent advances in high-throughput small RNA …
govern lipid metabolic phenotypes. Recent advances in high-throughput small RNA …
Role of angiopoietin-like 3 (ANGPTL3) in regulating plasma level of low-density lipoprotein cholesterol
Background and aims Angiopoietin-like 3 (ANGPTL3) has emerged as a key regulator of
lipoprotein metabolism in humans. Homozygous loss of ANGPTL3 function causes familial …
lipoprotein metabolism in humans. Homozygous loss of ANGPTL3 function causes familial …
[HTML][HTML] Microarray-based detection and expression analysis of new genes associated with drug resistance in ovarian cancer cell lines
R Januchowski, K Sterzyńska, P Zawierucha… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Purpose The present study is to discover a new genes associated with drug resistance
development in ovarian cancer. Methods We used microarray analysis to determine …
development in ovarian cancer. Methods We used microarray analysis to determine …
Systems genetics analysis of genome-wide association study reveals novel associations between key biological processes and coronary artery disease
Objective—Genome-wide association studies have identified multiple genetic variants
affecting the risk of coronary artery disease (CAD). However, individually these explain only …
affecting the risk of coronary artery disease (CAD). However, individually these explain only …
Prevalence of ANGPTL3 and APOB gene mutations in subjects with combined hypolipidemia
Objective—Mutations of the ANGPTL3 gene have been associated with a novel form of
primary hypobetalipoproteinemia, the combined hypolipidemia (cHLP), characterized by low …
primary hypobetalipoproteinemia, the combined hypolipidemia (cHLP), characterized by low …
Pathogens and fecal indicators in waste stabilization pond systems with direct reuse for irrigation: Fate and transport in water, soil and crops
ME Verbyla, MM Iriarte, AM Guzmán… - Science of the Total …, 2016 - Elsevier
Wastewater use for irrigation is expanding globally, and information about the fate and
transport of pathogens in wastewater systems is needed to complete microbial risk …
transport of pathogens in wastewater systems is needed to complete microbial risk …
A genome-wide association study of growth and fatness traits in two pig populations with different genetic backgrounds
Y Jiang, S Tang, C Wang, Y Wang, Y Qin… - Journal of animal …, 2018 - academic.oup.com
Improvement in growth and fatness traits are the main objectives in pig all breeding
programs. Tenth rib backfat thickness (10RIBBFT) and days to 100 kg (D100), which are …
programs. Tenth rib backfat thickness (10RIBBFT) and days to 100 kg (D100), which are …
Finding genes and variants for lipid levels after genome-wide association analysis
The goal of genetic studies for lipid levels is to improve treatment and ultimately reduce the
prevalence of heart disease. Many signals identified by GWAS have modest effect sizes …
prevalence of heart disease. Many signals identified by GWAS have modest effect sizes …