Biology and biomechanics of the heart valve extracellular matrix
KM Kodigepalli, K Thatcher, T West… - Journal of …, 2020 - mdpi.com
Heart valves are dynamic structures that, in the average human, open and close over
100,000 times per day, and 3× 109 times per lifetime to maintain unidirectional blood flow …
100,000 times per day, and 3× 109 times per lifetime to maintain unidirectional blood flow …
On the simulation of mitral valve function in health, disease, and treatment
The mitral valve (MV) is the left atrioventricular heart valve that regulates blood flow between
the left atrium and left ventricle (LV) during the cardiac cycle. Contrary to the aortic valve …
the left atrium and left ventricle (LV) during the cardiac cycle. Contrary to the aortic valve …
A detailed mechanical and microstructural analysis of ovine tricuspid valve leaflets
The tricuspid valve ensures unidirectional blood flow from the right atrium to the right
ventricle. The three tricuspid leaflets operate within a dynamic stress environment of shear …
ventricle. The three tricuspid leaflets operate within a dynamic stress environment of shear …
An investigation of regional variations in the biaxial mechanical properties and stress relaxation behaviors of porcine atrioventricular heart valve leaflets
The facilitation of proper blood flow through the heart depends on proper function of heart
valve components, and alterations to any component can lead to heart disease or failure …
valve components, and alterations to any component can lead to heart disease or failure …
A noninvasive method for the determination of in vivo mitral valve leaflet strains
Assessment of mitral valve (MV) function is important in many diagnostic, prognostic, and
surgical planning applications for treatment of MV disease. Yet, to date, there are no …
surgical planning applications for treatment of MV disease. Yet, to date, there are no …
The tricuspid valve also maladapts as shown in sheep with biventricular heart failure
Over 1.6 million Americans suffer from significant tricuspid valve leakage. In most cases this
leakage is designated as secondary. Thus, valve dysfunction is assumed to be due to valve …
leakage is designated as secondary. Thus, valve dysfunction is assumed to be due to valve …
Pre-surgical Prediction of Ischemic Mitral Regurgitation Recurrence Using In Vivo Mitral Valve Leaflet Strains
Ischemic mitral regurgitation (IMR) is a prevalent cardiac disease associated with substantial
morbidity and mortality. Contemporary surgical treatments continue to have limited long-term …
morbidity and mortality. Contemporary surgical treatments continue to have limited long-term …
[HTML][HTML] Mechanical strain induces a pro-fibrotic phenotype in human mitral valvular interstitial cells through RhoC/ROCK/MRTF-A and Erk1/2 signaling pathways
B Blomme, C Deroanne, A Hulin, C Lambert… - Journal of Molecular and …, 2019 - Elsevier
The mitral valve is a complex multilayered structure populated by fibroblast-like cells,
valvular interstitial cells (VIC) which are embedded in an extracellular matrix (ECM) scaffold …
valvular interstitial cells (VIC) which are embedded in an extracellular matrix (ECM) scaffold …
Development of a functionally equivalent model of the mitral valve chordae tendineae through topology optimization
Ischemic mitral regurgitation (IMR) is a currently prevalent disease in the US that is projected
to become increasingly common as the aging population grows. In recent years, image …
to become increasingly common as the aging population grows. In recent years, image …
An investigation of the effect of freezing storage on the biaxial mechanical properties of excised porcine tricuspid valve anterior leaflets
GA Duginski, CJ Ross, DW Laurence, CH Johns… - Journal of the …, 2020 - Elsevier
The atrioventricular heart valve (AHV) leaflets are critical to the facilitation of proper
unidirectional blood flow through the heart. Previously, studies have been conducted to …
unidirectional blood flow through the heart. Previously, studies have been conducted to …