Large animal models in regenerative medicine and tissue engineering: to do or not to do

I Ribitsch, PM Baptista, A Lange-Consiglio… - … in Bioengineering and …, 2020 - frontiersin.org
Rapid developments in Regenerative Medicine and Tissue Engineering has witnessed an
increasing drive toward clinical translation of breakthrough technologies. However, the …

Cell-and gene-based approaches to tendon regeneration

AJ Nixon, AE Watts, LV Schnabel - Journal of shoulder and elbow surgery, 2012 - Elsevier
Repair of rotator cuff tears in experimental models has been significantly improved by the
use of enhanced biologic approaches, including platelet-rich plasma, bone marrow aspirate …

Equine tendonitis therapy using mesenchymal stem cells and platelet concentrates: a randomized controlled trial

AM Carvalho, PR Badial, LEC Álvarez… - Stem cell research & …, 2013 - Springer
Introduction Tendon injury is a major cause of lameness and decreased performance in
athletic equines. Various therapies for tendonitis have been described; however, none of …

Comparison of autologous bone marrow and adipose tissue derived mesenchymal stem cells, and platelet rich plasma, for treating surgically induced lesions of the …

A Romero, L Barrachina, B Ranera, AR Remacha… - The Veterinary …, 2017 - Elsevier
Several therapies have been investigated for equine tendinopathies, but satisfactory long
term results have not been achieved consistently and a better understanding of the healing …

Tropism, pathology, and transmission of equine parvovirus-hepatitis

JE Tomlinson, M Jager, A Struzyna… - Emerging Microbes & …, 2020 - Taylor & Francis
Equine parvovirus-hepatitis (EqPV-H) has recently been associated with cases of Theiler's
disease, a form of fulminant hepatic necrosis in horses. To assess whether EqPV-H is the …

[HTML][HTML] Tenogenic modulating insider factor: Systematic assessment on the functions of tenomodulin gene

S Dex, D Lin, C Shukunami, D Docheva - Gene, 2016 - Elsevier
Tenomodulin (TNMD, Tnmd) is a gene highly expressed in tendon known to be important for
tendon maturation with key implications for the residing tendon stem/progenitor cells as well …

Achilles tendon injuries in elite athletes: lessons in pathophysiology from their equine counterparts

JC Patterson-Kane, T Rich - ILAR journal, 2014 - academic.oup.com
Superficial digital flexor tendon (SDFT) injury in equine athletes is one of the most well-
accepted, scientifically supported companion animal models of human disease (ie, exercise …

MicroRNA29a treatment improves early tendon injury

AE Watts, NL Millar, J Platt, SM Kitson, M Akbar… - Molecular Therapy, 2017 - cell.com
Tendon injuries (tendinopathies) are common in human and equine athletes and
characterized by dysregulated collagen matrix, resulting in tendon damage. We have …

Adipose micro-grafts enhance tendinopathy healing in ovine model: An in vivo experimental perspective study

A Palumbo Piccionello, V Riccio… - Stem Cells …, 2021 - academic.oup.com
Abstract In Europe, approximatively 100 000 to 500 000 tendon repairs are performed every
year. These procedures are associated with a considerable rate of postoperative …

Immunolocalization of collagens (I and III) and cartilage oligomeric matrix protein in the normal and injured equine superficial digital flexor tendon

F Södersten, K Hultenby, D Heinegård… - Connective tissue …, 2013 - Taylor & Francis
This is a descriptive study of tendon pathology with different structural appearances of repair
tissue correlated to immunolocalization of cartilage oligomeric matrix protein (COMP) and …