The observation that heart failure with reduced ejection fraction is associated with elevated
circulating levels of pro-inflammatory cytokines opened a new area of research that has …

Cardiac fibrosis is a common pathophysiologic companion of most myocardial diseases,
and is associated with systolic and diastolic dysfunction, arrhythmogenesis, and adverse …

The ECM (extracellular matrix) network plays a crucial role in cardiac homeostasis, not only
by providing structural support, but also by facilitating force transmission, and by transducing …

Background: Heart failure (HF) is a state of inappropriately sustained inflammation,
suggesting the loss of normal immunosuppressive mechanisms. Regulatory T-lymphocytes …

Background: Inflammation is associated with cardiac remodeling and heart failure, but how it
is initiated in response to nonischemic interventions in the absence of cell death is not …

Although chronic inflammation is a central feature of heart failure (HF), the immune cell
profiles differ with different underlying causes. This suggests that for immunomodulatory …

Myocardial inflammation can lead to lethal acute or chronic heart failure (HF). T lymphocytes
(T cells), have been reported in the inflamed heart in different etiologies of HF, and more …

Inflammation accompanies heart failure and is a mediator of cardiac fibrosis. CaMKIIδ plays
an essential role in adverse remodeling and decompensation to heart failure. We postulated …

Heart failure (HF) has been traditionally viewed as a disease of the cardiac muscle
associated with systemic inflammation. Burgeoning evidence implicates immune effector …

Almost 200 years ago, the first evidence described by Robert Bright (1836) showed the
strong interaction between the kidneys and heart and, since then, the scientific community …