Recent discoveries in cancer metabolism have revealed promising metabolic targets to
modulate cancer progression, drug response, and anti-cancer immunity. Combination …

Hematologic malignancies are one of the most common cancers, and the incidence has
been rising in recent decades. The clinical and molecular features of hematologic …

Opinion statement The search for effective therapies for the highly heterogenous disease
acute myeloid leukemia (AML) has remained elusive. While cytotoxic therapies can induce …

Of the many genetic alterations that occur in cancer, relatively few have proven to be
suitable for the development of targeted therapies. Mutations in isocitrate dehydrogenase …

Oral azacitidine (oral-Aza) treatment results in longer median overall survival (OS)(24.7 vs.
14.8 months in placebo) in patients with acute myeloid leukemia (AML) in remission after …

Hematopoiesis is an essential process for organismal development and homeostasis.
Epigenetic regulation of gene expression is critical for stem cell self-renewal and …

Simple Summary Acute myeloid leukemia (AML) arises from a stepwise acquisition of
multiple genetic alterations in the hematopoietic stem and progenitor cell and is …

The ubiquitous metabolite heme has diverse enzymatic and signalling functions in most
mammalian cells. Cells can salvage heme from the extracellular environment or synthesise …

Limited information exists about the cellular distribution of mutations which persist in
remission in acute myeloid leukemia (AML)(variably considered pre-leukemic mutations) …

How hematopoietic stem and progenitor cell (HSPC) fate decisions are affected by genetic
alterations acquired during AML leukemogenesis is poorly understood and mainly explored …