Understanding lipotoxicity in NAFLD pathogenesis: is CD36 a key driver?

P Rada, Á González-Rodríguez, C García-Monzón… - Cell death & …, 2020 - nature.com
Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease
worldwide. NAFLD stages range from simple steatosis (NAFL) to non-alcoholic …

Therapeutic targets, novel drugs, and delivery systems for diabetes associated NAFLD and liver fibrosis

V Kumar, X Xin, J Ma, C Tan, N Osna… - Advanced drug delivery …, 2021 - Elsevier
Type 2 diabetes mellitus (T2DM) associated non-alcoholic fatty liver disease (NAFLD) is the
fourth-leading cause of death. Hyperglycemia induces various complications, including …

[HTML][HTML] A position statement on NAFLD/NASH based on the EASL 2009 special conference

V Ratziu, S Bellentani, H Cortez-Pinto… - Journal of …, 2010 - journal-of-hepatology.eu
Nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) are
increasingly relevant public health issues owing to their close association with the …

Lipotoxic lethal and sublethal stress signaling in hepatocytes: relevance to NASH pathogenesis [S]

P Hirsova, SH Ibrabim, GJ Gores, H Malhi - Journal of lipid research, 2016 - ASBMB
The accumulation of lipids is a histologic and biochemical hallmark of obesity-associated
nonalcoholic fatty liver disease (NAFLD). A subset of NALFD patients develops progressive …

Experimental liver fibrosis research: update on animal models, legal issues and translational aspects

C Liedtke, T Luedde, T Sauerbruch, D Scholten… - Fibrogenesis & tissue …, 2013 - Springer
Liver fibrosis is defined as excessive extracellular matrix deposition and is based on
complex interactions between matrix-producing hepatic stellate cells and an abundance of …

[PDF][PDF] Homozygosity for the patatin‐like phospholipase‐3/adiponutrin I148M polymorphism influences liver fibrosis in patients with nonalcoholic fatty liver disease

L Valenti, A Al‐Serri, AK Daly, E Galmozzi… - …, 2010 - Wiley Online Library
Inherited factors play a major role in the predisposition to nonalcoholic fatty liver disease
(NAFLD), and the rs738409 C→ G polymorphism of PNPLA3/adiponutrin, encoding for the …

Gut microbiota, lipopolysaccharides, and innate immunity in the pathogenesis of obesity and cardiovascular risk

M Manco, L Putignani, GF Bottazzo - Endocrine reviews, 2010 - academic.oup.com
Compelling evidence supports the concepts that gut microbiota actively promotes weight
gain and fat accumulation and sustains, indirectly, a condition of low-grade inflammation …

Principles of liver regeneration and growth homeostasis

GK Michalopoulos - Comprehensive physiology, 2013 - Wiley Online Library
Liver regeneration is perhaps the most studied example of compensatory growth aimed to
replace loss of tissue in an organ. Hepatocytes, the main functional cells of the liver, manage …

Adipocyte apoptosis, a link between obesity, insulin resistance, and hepatic steatosis

N Alkhouri, A Gornicka, MP Berk, S Thapaliya… - Journal of Biological …, 2010 - ASBMB
Adipocyte death has been reported in both obese humans and rodents. However, its role in
metabolic disorders, including insulin resistance, hepatic steatosis, and inflammation …

[HTML][HTML] Death receptor-mediated cell death and proinflammatory signaling in nonalcoholic steatohepatitis

P Hirsova, GJ Gores - Cellular and molecular gastroenterology and …, 2015 - Elsevier
Nonalcoholic fatty liver disease (NAFLD) is becoming a public health problem worldwide. A
subset of patients develop an inflammatory disease, nonalcoholic steatohepatitis (NASH) …