Genomics for public health and international surveillance of antimicrobial resistance

KS Baker, E Jauneikaite, KL Hopkins, SW Lo… - The Lancet …, 2023 - thelancet.com
Historically, epidemiological investigation and surveillance for bacterial antimicrobial
resistance (AMR) has relied on low-resolution isolate-based phenotypic analyses …

Combination of whole genome sequencing and metagenomics for microbiological diagnostics

S Purushothaman, M Meola, A Egli - International journal of molecular …, 2022 - mdpi.com
Whole genome sequencing (WGS) provides the highest resolution for genome-based
species identification and can provide insight into the antimicrobial resistance and virulence …

ESKAPE pathogens: antimicrobial resistance, epidemiology, clinical impact and therapeutics

WR Miller, CA Arias - Nature Reviews Microbiology, 2024 - nature.com
The rise of antibiotic resistance and a dwindling antimicrobial pipeline have been
recognized as emerging threats to public health. The ESKAPE pathogens—Enterococcus …

Carbapenem-resistant Klebsiella pneumoniae: the role of plasmids in emergence, dissemination, and evolution of a major clinical challenge

V Di Pilato, S Pollini, V Miriagou… - Expert Review of Anti …, 2024 - Taylor & Francis
Introduction Klebsiella pneumoniae is a major agent of healthcare-associated infections and
a cause of some community-acquired infections, including severe bacteremic infections …

Clonal background and routes of plasmid transmission underlie antimicrobial resistance features of bloodstream Klebsiella pneumoniae

OO Ikhimiukor, NI Zac Soligno, IJ Akintayo… - Nature …, 2024 - nature.com
Bloodstream infections caused by the opportunistic pathogen Klebsiella pneumoniae are
associated with adverse health complications and high mortality rates. Antimicrobial …

Plasmid genomic epidemiology of blaKPC carbapenemase-producing Enterobacterales in Canada, 2010–2021

N Lerminiaux, R Mitchell, J Bartoszko… - Antimicrobial Agents …, 2023 - Am Soc Microbiol
Carbapenems are considered last-resort antibiotics for the treatment of infections caused by
multidrug-resistant Enterobacterales, but carbapenem resistance due to acquisition of …

A panel of diverse Klebsiella pneumoniae clinical isolates for research and development

MJ Martin, W Stribling, AC Ong… - Microbial …, 2023 - microbiologyresearch.org
Klebsiella pneumoniae are a leading cause of healthcare-associated infections worldwide.
In particular, strains expressing extended-spectrum β-lactamases (ESBLs) and …

A Comprehensive Genomic Analysis of the Emergent Klebsiella pneumoniae ST16 Lineage: Virulence, Antimicrobial Resistance and a Comparison with the …

RO de Sales, L Leaden, LB Migliorini, P Severino - Pathogens, 2022 - mdpi.com
Klebsiella pneumoniae is considered an opportunistic pathogen frequently involved with
healthcare-associated infections. The genome of K. pneumoniae is versatile, harbors …

Systematic analysis of mobile genetic elements mediating β-lactamase gene amplification in noncarbapenemase-producing carbapenem-resistant Enterobacterales …

WC Shropshire, A Konovalova, P McDaneld, M Gohel… - Msystems, 2022 - Am Soc Microbiol
Noncarbapenemase-producing carbapenem-resistant Enterobacterales (non-CP-CRE) are
increasingly recognized as important contributors to prevalent carbapenem-resistant …

Genetic plurality of blaKPC-2-harboring plasmids in high-risk clones of Klebsiella pneumoniae of environmental origin

JPR Furlan, R da Silva Rosa, MS Ramos… - Science of The Total …, 2023 - Elsevier
International high-risk clones of Klebsiella pneumoniae are important human pathogens that
are spreading to the environment. In the COVID-19 pandemic scenario, the frequency of …