Amino acid metabolism in health and disease

ZN Ling, YF Jiang, JN Ru, JH Lu, B Ding… - Signal Transduction and …, 2023 - nature.com
Amino acids are the building blocks of protein synthesis. They are structural elements and
energy sources of cells necessary for normal cell growth, differentiation and function. Amino …

The role of protein kinases as key drivers of metabolic dysfunction-associated fatty liver disease progression: New insights and future directions

S Alshehade, MA Alshawsh, V Murugaiyah, M Asif… - Life sciences, 2022 - Elsevier
Metabolic dysfunction-associated fatty liver disease (MAFLD), proposed in 2020 is a novel
term for non-alcoholic fatty liver disease (NAFLD) which was coined for the first time in 1980 …

An update on animal models of liver fibrosis

ST Wu, XX Wang, WB Xing, FY Li, M Liang, KS Li… - Frontiers in …, 2023 - frontiersin.org
The development of liver fibrosis primarily determines quality of life as well as prognosis.
Animal models are often used to model and understand the underlying mechanisms of …

Formononetin promotes fatty acid β-oxidation to treat non-alcoholic steatohepatitis through SIRT1/PGC-1α/PPARα pathway

J Liao, X Xie, N Wang, Y Wang, J Zhao, F Chen, F Qu… - Phytomedicine, 2024 - Elsevier
Background Non-alcoholic steatohepatitis (NASH), the progressive form of non-alcoholic
fatty liver disease (NAFLD), carries a high risk of cirrhosis and hepatocellular carcinoma …

Theabrownin ameliorates liver inflammation, oxidative stress, and fibrosis in MCD diet-fed C57BL/6J mice

Q Zhen, Q Liang, H Wang, Y Zheng, Z Lu… - Frontiers in …, 2023 - frontiersin.org
Introduction Nonalcoholic steatohepatitis (NASH), also known as metabolic steatohepatitis,
is a clinical syndrome with pathological changes like alcoholic hepatitis but without a history …

Research progress regarding the effect and mechanism of dietary phenolic acids for improving nonalcoholic fatty liver disease via gut microbiota

L Ji, H Deng, H Xue, J Wang, K Hong… - … Reviews in Food …, 2023 - Wiley Online Library
Phenolic acids (PAs), a class of small bioactive molecules widely distributed in food and
mainly found as secondary plant metabolites, present significant advantages such as …

[HTML][HTML] A novel A2a adenosine receptor inhibitor effectively mitigates hepatic fibrosis in a metabolic dysfunction-associated steatohepatitis mouse model

S Park, S Hwang, J Sun, KH Jeon… - … Journal of Biological …, 2024 - ncbi.nlm.nih.gov
Hepatic fibrosis exacerbates mortality and complications in progressive metabolic
dysfunction-associated steatohepatitis (MASH). The role of the adenosine 2A receptor …

[HTML][HTML] Total flavonoids of litchi Seed alleviates schistosomiasis liver fibrosis in mice by suppressing hepatic stellate cells activation and modulating the gut …

Q Li, J Wang, J Lv, D Liu, S Xiao, J Mo, Z Lu… - Biomedicine & …, 2024 - Elsevier
Infection with Schistosoma japonicum (S. japonicum) is an important zoonotic parasitic
disease that causes liver fibrosis in both human and domestic animals. The activation of …

LncRNA Snhg3 aggravates hepatic steatosis via PPARγ signaling

X Xie, M Gao, W Zhao, C Li, W Zhang, J Yang, Y Zhang… - Elife, 2024 - elifesciences.org
LncRNAs are involved in modulating the individual risk and the severity of progression in
metabolic dysfunction-associated fatty liver disease (MASLD), but their precise roles remain …

[HTML][HTML] Single-cell transcriptomics reveals CD8+ T cell structure and developmental trajectories in idiopathic pulmonary fibrosis

X Wei, C Jin, D Li, Y Wang, S Zheng, Q Feng… - Molecular …, 2024 - Elsevier
Immune cells in the human lung are associated with idiopathic pulmonary fibrosis. However,
the contribution of different immune cell subpopulations to the pathogenesis of pulmonary …