MHC genotypes associate with resistance to a frog-killing fungus

AE Savage, KR Zamudio - Proceedings of the National …, 2011 - National Acad Sciences
The emerging amphibian disease chytridiomycosis is caused by the fungal pathogen
Batrachochytrium dendrobatidis (Bd). Amphibian populations and species differ in …

Adaptive tolerance to a pathogenic fungus drives major histocompatibility complex evolution in natural amphibian populations

AE Savage, KR Zamudio - Proceedings of the Royal …, 2016 - royalsocietypublishing.org
Amphibians have been affected globally by the disease chytridiomycosis, caused by the
fungus Batrachochytrium dendrobatidis (Bd), and we are just now beginning to understand …

Linking genetic and environmental factors in amphibian disease risk

AE Savage, CG Becker… - Evolutionary Applications, 2015 - Wiley Online Library
A central question in evolutionary biology is how interactions between organisms and the
environment shape genetic differentiation. The pathogen Batrachochytrium dendrobatidis …

Eco‐evolutionary rescue promotes host–pathogen coexistence

GV DiRenzo, EF Zipkin, EHC Grant… - Ecological …, 2018 - Wiley Online Library
Emerging infectious pathogens are responsible for some of the most severe host mass
mortality events in wild populations. Yet, effective pathogen control strategies are notoriously …

Differences in sensitivity to the fungal pathogen Batrachochytrium dendrobatidis among amphibian populations

PW Bradley, SS Gervasi, J Hua… - Conservation …, 2015 - Wiley Online Library
Contributing to the worldwide biodiversity crisis are emerging infectious diseases, which can
lead to extirpations and extinctions of hosts. For example, the infectious fungal pathogen …

Conservation phylogeography: does historical diversity contribute to regional vulnerability in European tree frogs (Hyla arborea)?

C Dufresnes, J Wassef, K Ghali, A Brelsford… - Molecular …, 2013 - Wiley Online Library
Documenting and preserving the genetic diversity of populations, which conditions their long‐
term survival, have become a major issue in conservation biology. The loss of diversity often …

The Amphibian Major Histocompatibility Complex—A Review and Future Outlook

J Sabino-Pinto, ME Maan - Journal of Molecular Evolution, 2025 - Springer
The major histocompatibility complex (MHC) is a cluster of functionally related genes
encoding proteins which, among other functions, mediate immune system activation. While …

Importance of Genetic–Fitness Correlations for the Conservation of Amphibians

H Pröhl, A Rodríguez - Animals, 2023 - mdpi.com
Simple Summary Threatened animal species live in small and isolated populations, often
with a reduced number of individuals and reduced genetic diversity. In this review, we …

Genetic diversity of MHC class I loci in six non-model frogs is shaped by positive selection and gene duplication

KM Kiemnec-Tyburczy, JQ Richmond, AE Savage… - Heredity, 2012 - nature.com
Comparative studies of major histocompatibility complex (MHC) genes across vertebrate
species can reveal the evolutionary processes that shape the structure and function of …

Immune priming prior to pathogen exposure sheds light on the relationship between host, microbiome and pathogen in disease

AW Kaganer, RJ Ossiboff, NI Keith… - Royal Society …, 2023 - royalsocietypublishing.org
Dynamic interactions between host, pathogen and host-associated microbiome dictate
infection outcomes. Pathogens including Batrachochytrium dendrobatidis (Bd) threaten …