Cannabinoid receptors: An update on cell signaling, pathophysiological roles and therapeutic opportunities in neurological, cardiovascular, and inflammatory …
The identification of the human cannabinoid receptors and their roles in health and disease,
has been one of the most significant biochemical and pharmacological advancements to …
has been one of the most significant biochemical and pharmacological advancements to …
Endocannabinoid system in neurodegenerative disorders
BS Basavarajappa, M Shivakumar… - Journal of …, 2017 - Wiley Online Library
Most neurodegenerative disorders (NDD s) are characterized by cognitive impairment and
other neurological defects. The definite cause of and pathways underlying the progression …
other neurological defects. The definite cause of and pathways underlying the progression …
Cannabinoid CB1 and CB2 Receptor Signaling and Bias
An agonist that acts through a single receptor can activate numerous signaling pathways.
Recent studies have suggested that different ligands can differentially activate these …
Recent studies have suggested that different ligands can differentially activate these …
Cannabinoids inhibit glioma cell invasion by down-regulating matrix metalloproteinase-2 expression
C Blázquez, M Salazar, A Carracedo, M Lorente… - Cancer research, 2008 - AACR
Cannabinoids, the active components of Cannabis sativa L. and their derivatives, inhibit
tumor growth in laboratory animals by inducing apoptosis of tumor cells and impairing tumor …
tumor growth in laboratory animals by inducing apoptosis of tumor cells and impairing tumor …
Insights into biased signaling at cannabinoid receptors: synthetic cannabinoid receptor agonists
E Wouters, J Walraed, SD Banister, CP Stove - Biochemical pharmacology, 2019 - Elsevier
Abstract Cannabinoid receptors type 1 (CB 1) and type 2 (CB 2) are promising targets for a
number of diseases, including obesity, neuropathic pain, and multiple sclerosis, among …
number of diseases, including obesity, neuropathic pain, and multiple sclerosis, among …
Cannabinoids as immune system modulators: Cannabidiol potential therapeutic approaches and limitations
Introduction: Cannabidiol (CBD) is the second most abundant Phytocannabinoid in
Cannabis extracts. CBD has a binding affinity for several cannabinoid and cannabinoid …
Cannabis extracts. CBD has a binding affinity for several cannabinoid and cannabinoid …
ERK activation pathways downstream of GPCRs
Abstract GPCRs, the 7-TM receptors, represent a class of cell surface receptors which
modulate a variety of physiological responses. The serpentine structure in addition to …
modulate a variety of physiological responses. The serpentine structure in addition to …
Pharmacological selection of cannabinoid receptor effectors: Signalling, allosteric modulation and bias
The type-1 cannabinoid receptor (CB 1) is a promising drug target for a wide range of
diseases. However, many existing and novel candidate ligands for CB 1 have shown only …
diseases. However, many existing and novel candidate ligands for CB 1 have shown only …
Cannabinoid Receptor 2 (CB2) Signals via G-alpha-s and Induces IL-6 and IL-10 Cytokine Secretion in Human Primary Leukocytes
Cannabinoid receptor 2 (CB2) is a promising therapeutic target for immunological
modulation. There is, however, a deficit of knowledge regarding CB2 signaling and function …
modulation. There is, however, a deficit of knowledge regarding CB2 signaling and function …
Specific detection of CB1 receptors; cannabinoid CB1 receptor antibodies are not all created equal!
NL Grimsey, CE Goodfellow, EL Scotter… - Journal of neuroscience …, 2008 - Elsevier
The study of endogenous cannabinoid CB1 receptor proteins in neuronal tissues and cells
relies on the availability of highly specific antibodies. We have tested the ability of a series of …
relies on the availability of highly specific antibodies. We have tested the ability of a series of …