Vertebrates and insects have evolved complex repertoires of chemosensory receptors to
detect and distinguish odours. With a few exceptions, vertebrate chemosensory receptors …

Mammalian Na+/Ca2+ exchangers are members of three branches of a much larger family
of transport proteins [the CaCA (Ca2+/cation antiporter) superfamily] whose main role is to …

Loss of function of the gene SCN9A, encoding the voltage-gated sodium channel Nav1. 7,
causes a congenital inability to experience pain in humans. Here we show that Nav1. 7 is …

Olfactory receptors (ORs) detect volatile chemicals that lead to the initial perception of smell
in the brain. The olfactory receptor (OR) is the first protein that recognizes odorants in the …

Sensing the chemical warnings present in the environment is essential for species survival.
In mammals, this form of danger communication occurs via the release of natural predator …

Most vertebrate olfactory receptor neurons share a common G-protein–coupled pathway for
transducing the binding of odorant into depolarization. The depolarization involves 2 …

Olfactory receptors (ORs) and down-stream functional signaling molecules adenylyl cyclase
3 (AC3), olfactory G protein α subunit (Gαolf), OR transporters receptor transporter proteins 1 …

Sensory perception requires accurate encoding of stimulus information by sensory receptor
cells. We identified NCKX4, a potassium-dependent Na+/Ca2+ exchanger, as being …

Comprehensive Overview of Advances in OlfactionThe common belief is that human smell
perception is much reduced compared with other mammals, so that whatever abilities are …

Most animals have evolved multiple olfactory systems to detect general odors as well as
social cues. The sophistication and interaction of these systems permit precise detection of …